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February 9, 2012
| Bio-IT World
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Industry Trends

Next Generation Sequencing Generates Momentum: Markets Respond to Technology and Innovation Advances - Overview

Author: Ken Rubenstein, PhD

This report focuses on current and innovative NGS technologies, services and markets to answer such questions as:

  • Which early NGS market entrants have been continually improving and updating their original systems?
  • Who has introduced new scaled-down instruments to broaden the market?
  • What Generation 2.5 systems featuring new detection technologies and single-molecule sequencing are now on the market?
  • When will third generation of instruments led by nanopore technologies be entering the commercial feasibility stage?
  • Why upstream sample handling is undergoing continual technological innovation?
  • Which informatics providers are moving rapidly toward fully integrated systems to provide the rapid generation of actionable biological information?

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Bio-IT World Best Practices Award: Submit your entry today … Deadline is February 15th!
This prestigious awards program is designed to recognize outstanding examples of technology and strategic innovation—initiatives and collaborations that manifestly improve some facet of the R&D/drug development/clinical trial process.
Click here to learn more.  

Top Headlines


San Diego Gets Bulk of California NIH Grants
TODAY | San Diego Source | A new PricewaterhouseCoopers report shows that three of the top 10 California recipients of National Institutes of Health grants were in the San Diego area. more
Scientific Collaboration in New York
TODAY | Xconomy | The New York Genome Center will open this month, and the New York eHealth Collaborative held its first conference last year. It's been a season of collaboration for scientific organizations in the New York area. more
Flatley Flatly Rejects Roche Unsolicited Bid for Illumina
Feb 08 | BusinessWire | Illumina CEO Jay Flatley has informed Roche that its unsolicited tender offer of $44.50 per share is "grossly inadequate in multiple respects, dramatically undervalues Illumina and is contrary to the best interests of Illumina's stockholders." more
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Laying the Foundation for Next-Gen Cancer Diagnostics
Feb 08 | Bio-IT World | This summer, Foundation Medicine will launch what could be described as the next generation of cancer diagnostics. The Cambridge, Mass.-based company, founded by a premier group of cancer researchers and funded by Third Rock Ventures, Kleiner Perkins Caufield & Byers and Google Ventures, will launch a comprehensive next-gen sequencing (NGS) profile screening some about 200 genes known to be clinically relevant and actionable in cancer using routine, formalin-fixed paraffin embedded patient cancer specimens.  more
Warp Drive Bio Charts Course for Natural Product Drugs
Feb 08 | Bio-IT World | While many major pharma companies have been cutting back their research into natural products, Warp Drive Bio, a new start-up out of Third Rock Ventures in Boston, is dedicated to mining the genome of micro-organisms for potent natural product compounds. And in a striking $125-million deal, Warp Drive has teamed with Sanofi to provide ample funding to get operations off the ground and potentially into orbit.  more
Picture Perfect: Imaging in Drug Discovery and Translational Medicine
Feb 07 | Bio-IT World | Imaging in drug discovery has been rising to the forefront of conversations more and more recently. Managing editor Allison Proffitt spoke with Ken Kilgore, Director of Immunology Pharmacology at Janssen Research & Development (formerly Centocor Research & Development), a Johnson & Johnson company, about how—and why—imaging’s role is changing in drug discovery. more

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White Papers & Special Reports

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Managing the Modern Genomics Data Flood
Sponsored by SGI

Managing and storing the perfect storm of multi-disciplined data pouring from next generation sequencers and other omics instruments is a central challenge in life sciences. Discover in this paper how the SGI ArcFiniti storage solution, optimized for unstructured genomics and life sciences data can: 

  • Reduce costs, proactively protect data integrity, and deliver the high performance I/O required for genomics data processing and analysis.  
  • Effectively manage capacities from 156TB to 1.4PB as a disk based, integrated hardware and software platform 
COMPLIMENTARY DOWNLOAD
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Turning Genomics Data into Practical Insight
Sponsored by SGI

With worldwide sequencing capacity approaching 13 quadrillion DNA bases annually turning genomics data into knowledge is a true computational challenge. Read this paper and learn how the SGI UV coherent shared memory platform can:  

  • Speed results time while cost competitively tackling the most difficult computational problems across all omics disciplines. 
  • Push performance by scaling to extraordinary levels, up to 256 sockets (2,560 cores, 4,096 threads) per single system (one OS image). 

Provide support for up to 16TB of coherent shared memory in a single system image enabling extreme efficiency across a wide range of compute demands. 

COMPLIMENTARY DOWNLOAD
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New Complimentary Market Survey…
Collaborations and Communications Within Drug Discovery Research
Sponsored by Accelrys
This survey was conducted by the Cambridge Healthtech Media Group in January, 2012. It was sponsored by Accelrys related to their HEOS initiative to gather valid information around externalizing collaborative research while improving communications in the cloud. With 310 qualified industry respondents the survey findings reveal useful usage and trends patterns.  An insightful follow-on discussion and webinar related to this survey, and the HEOS by Scynexis SaaS portal is also available on the Bio-IT World website for complementary viewing.
 
DOWNLOAD SURVEY NOW
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NEW from Bio-IT World


Expert Comment

What Should We Call 'Systems Biology'?

By Desmond Smith

Systems biology lies at the very heart of modern biomedical research and a number of review articles and conferences have caught the spirit of this movement. The discipline encompasses an assortment of related but distinct concepts, including the idea that detailed and comprehensive data from living systems will enable robust prediction of their trajectory and also the paradoxical notion that some biological behaviors occur in a relatively surprising and unexpected fashion, so-called emergent properties.

However, the ideas underlying systems biology are not new. First articulated by a number of researchers in the 1960s, some of the principal notions were also articulated by Francis Crick in a visionary Nature review article in 1970 that anticipated the state of molecular biology in the year 2000. In his article (Nature 228, 613-615 (Nov 1970)), Crick stated that “problems involving complex interactions can hardly be avoided… a simple example would be the ‘total’ behavior of a microorganism such as Escherichia coli, including all of its regulatory mechanisms.” Read more. Bio-IT World invites contributed Expert Commentaries. Contact Kevin Davies with proposals.  

Life Science Webcasts & Podcasts

medidata podcast #8 Meeting Today’s Challenges in Clinical Trial Supply Management
Sponsored by: Medidata Solutions Worldwide  

Setting up and managing the clinical trial involves many complex procedures. Among the most challenging are planning and executing the logistics of the trial’s clinical supplies. This podcast focuses in depth on the following topics which trace current practices and future evolution of this crucial aspect of clinical trials:

  • Current practices in clinical trial logistics
  • Comparing advances in clinical supply practices to  other aspects of clinical trials 
  • Where current practices fall short of meeting the challenges
  • Trends and evolving improvements that may change the way logistics are conducted

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