COVER STORY
Working Out the Flow
Life-science informatics companies help biotechnology and pharmaceutical scientists smooth out workflow, and aspire to provide new knowledge.
By Mike May

Up Front

• IBM Races H5N1
  Global Pandemic Initiative includes effort to speed up flu virus's evolution in silico.
• The $2 Billion Pill? 
  Lilly executive issues drug costs warning in DDT keynote speech.
• Getting a Handle on Systems Biology 
  SYSTEMS BIOLOGY - Introducing guest columnist Nat Goodman's series of online articles.
  By Nat Goodman
• Assays and Knowledgebases for Genomic Analysis
  FULLY EQUIPPED - Handling knowledge is a key issue for drug discovery and development.
  By Robert M. Frederickson
• News Briefs

Computational Biology

• Predicting the Future of Systems Biology
  An in-depth conversation with Genstruct CEO, Keith Elliston.
• Informatics Cornucopia
  DDT coverage:  NCI's tool set; systems biology panel.
• Bioinformatics Is Going Back to School
  DOL initiatives aimed at revamping Bio-IT curriculum.
• Integrating Knowledge
  Harnessing mathematics in drug discovery.
  

Computational Development

• Pfizer's Global Survey of Pharmacological Space
  KnowledgeBase of 4.8 million compounds spurs predictive models. 

IT/Workflow

• TIGR Unplugs HP, Switches to Sun for Genome Assembly
  High performance, throughput provides high-quality data.
• Apple's Leopard Raises OS Ante
  New features and improved ease of use give life science IT pros a boost.

Clinical Research

• Spotfire: Seeing Your Clinical Trial Data Jump
  Visualization experts move beyond drug discovery data.

• Data Standards: Are We at the Tipping Point?
  How will clinical data standards adoption affect clinical research drug development and safety management?

In Every Issue

• Predictive Biology and Medicine
  FIRST BASE - Predictive, personalized, and preemptive medicine; and a new look for Bio-IT World.
  By Kevin Davies 
• On the Threshold of Systems Biology
  THE RUSSELL TRANSCRIPT - Are we nearing an inflection point for systems biology?
  By John Russell
• New Products