COVER STORY
Exploratory INDs: A Trial Before the Trials
Phase 0 trials and the use of tiny drug doses are gaining acceptance and winning converts.

Up Front

• Sequencing Stories and Start-Ups 
  CHI's second next-generation sequencing conference showcases the first personal genomes and future technologies.
• VCs Should Go Back to School
  NOTHING VENTURED - Academia is a ripe environment for promising investment opportunities.
  By Michael A. Greeley
• OSINT and the Pharmaceutical Enterprise - Part 2
  INSIGHTS/OUTLOOK - Making the most of Open Source Intelligence means a tailored and refined discovery and analysis process.
  By James B. Golden
• SNPedia: A Wiki for Personal Genomics
  INSIDE THE BOX - SNP's wikipedia puts genetic data in the hands of the recreational genomic crowd.
  By Michael Cariaso
• Briefs 

• Swinging Through the Proteomic Jungle
  HUPO meeting stresses need for standardized analysis methods and a workflow focus. 

Computational Development

• Extracting Information in Life Sciences
  Through the BioCreative competition, MITRE's Lynette Hirshman helps raise the performance and relevance of academic text mining solutions.

 IT/Workflow

• Reynders Takes the CIO Reins at J&J R&D
  He lists translational science and integration as key challenges.
• Emerging Trends in Top500 Supercomputer List
  BlueGene once again finds itself on top.
• BlueArc's Titan 1100 Targets Cost-Conscious
  Newest model cuts costs.
• Information Capture Across Organizations
  COMMENTARY - Organizational changes are crucial to connect discovery teams.
• Harnessing Multi-Core Personal Computers
  COMMENTARY - Scientists and IT groups create ROI.
  

Clinical Research

• Standards Questions
  CDISC's Becky Kush looks forward to new FDA rules.
• New Mindset about eClinical Technologies
  EXCLUSIVE - Tufts CSDD survey shows shift toward technologies.

In Every Issue

• Inside Andy Grove's World of Bio-IT 
  FIRST BASE - Grove challenges pharma to take a semiconductor industry approach.
  By Kevin Davies
• Bio-IT World Best Practices 2008
  THE RUSSELL TRANSCRIPT - Best Practices competition will recognize technological innovation and excellence in 2008.
  By John Russell
• New Products