COVER STORY
Data Management: The Next Generation 
New technologies aim to simplify data management while meeting life sciences' soaring computation performance requirements.

Up Front

• Single Minded Sequencing
  Helicos prepares to unveil its long-awaited "DNA microscope."
• Applied Bio Software Initiative for Next-Gen
  Development plan enables analysis software.
• Metagenomics on the Case
  454 finds clues to the mystery of colony collapse disorder.
• Wyeth's Approach to Clinical Biomarkers
  THE BIOMARKER REPORT - Wyeth depends on biomarkers early in development.
  By Malorye Allison
• Next-Generation Sequencing Problems and Solutions
  INSIDE THE BOX - Solving next-gen challenges.
  By William Van Etten
• Connecting Neuroscience Knowledge
  SCIENCE AND THE WEB - Managing information capture and analysis in neuroscience.
  By Eric K. Neumann
• Briefs 

• The Pathway Is the Target
  Avalon Pharmaceuticals focuses on signatures and scale in drug discovery, aims for entire pathway.
• Data Warehousing Project for the NIH
  Northrup Grumman curates two data warehouses for NIAID. 

Computational Development

• Drug Redux
  Gene Logic and others recycle failed drug candidates, in high-tech style.

 IT/Workflow

• SciLink Scours the Web for Connections
  New Website reduces the "tedium of networking."
• Kelaroo Releases Sequence Profiling Tool
  In advance of the release of a new SeqR tool, Kelaroo expands their Amylin contract research.

Clinical Research

• Life on EDC Street
  Analysts looking at the growing EDC market see Phase Forward, Medidata leading the crop.
• Decisions, Decisions on Adaptive Research
  Fast, clean data and performance metrics are key for adaptive trials, says CEO of Health Decisions.

In Every Issue

• From Best Practices to Navigenics
  FIRST BASE - Dietrich Stephan plans to offer "newborn screening for adults."
  By Kevin Davies
• Optimata: Eyes on the Prize
  THE RUSSELL TRANSCRIPT - Israeli systems biology company wades into drug repositioning.
  By John Russell
• New Products