In Living Color
Fluorescent proteins for a new palette (or palate).
BY KEVIN DAVIES
Researchers at the University of California at San Diego, led by Roger Tsien, have developed a dazzling palette of fluorescent proteins to complement the green fluorescent protein (GFP), a stable of cell biology for a decade.
The new proteins have been dubbed the names of fruits, including honeydew, banana, tangerine, strawberry, cherry, and raspberry. "Just as no one type of fruit in a grocery store supplants all others, there is no single best fluorescent protein within the cornucopia," Tsien says.
Potential applications include the discrimination of multiple cell types, transcriptional activities, and fusion proteins. The fruity proteins were unveiled by Shaner et al. in the December 2004 issue of Nature Biotechnology.
The 2004 Palette of Monomeric Fluorescent Proteins