Tuesday, November 6, 2012    |    
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THIS WEEK IN BIO-IT WORLD  

How to Design a Better Double Helix
Bio-IT World | The Double Helix by James D. Watson is not merely a magnificent scientific detective story
but one of the classics of 20th century literature. The book was originally published in 1968, six years
after Watson shared the Nobel Prize with Francis Crick and Maurice Wilkins, and despite the objections
of many principals in the saga. Watson's gripping, painfully honest account of the quest to puzzle the
structure of DNA in the face of mass distractions. So how does one improve upon a classic? One doesn't try.
But inspired by the serendipitous discovery of the lost correspondence of Francis Crick a few years ago,
two veteran Cold Spring Harbor Laboratory faculty decided to produce an enhanced edition of the book, which
is published this week in conjunction with Simon & Schuster. On the eve of publication, Bio-IT World invited
the editors of the new book, Alex Gann and Jan Witkowski, to discuss the background to the project and
preview some of the treasures within. Read More
 

Bio-IT World Launches 2013 Best Practices Program
Bio-IT World | The 2013 Bio-IT World Best Practices competition has released its Call for Entries. Since 2003,
Bio-IT World's Best Practices competition has been recognizing outstanding examples of technology and
strategic innovation initiatives across the biomedical and drug discovery enterprise. The deadline for entry
is January 11, 2013, and the early bird deadline is December 14, 2012. Read More
 

Oxford Nanopore and Illumina in Arbitration Regarding Sequencing Partnership
Bio-IT World | In an analyst research note issued last week, Charles Weston, director of equity research at
Numis Securities Ltd in London, spotlighted a legal proceeding between Oxford Nanopore Technologies and
Illumina, an early investor in the company. Read More
 

In Conversation: Tufts Geneticist Diana Bianchi on Noninvasive Prenatal Testing
Bio-IT World | One year after the commercial debut of the first noninvasive prenatal test for aneuploidy by
Sequenom, the technology is seeing rapid uptake and development by a handful of diagnostics start-ups. Diana
Bianchi, an expert in noninvasive prenatal testing at Tufts Medical Center an to Verinata Health, discusses the
exciting advances in this field. Read More
 

King's Proclamation for Citizen Scientists
Bio-IT World | First Base | One of the most electrifying scientific presentations I've ever heard--complete with
a rare standing ovation--came nearly two decades ago at the American Society of Human Genetics (ASHG) annual
convention. The woman who gave those remarks--Mary-Claire King--is now the president of ASHG and will likely
inspire thousands in attendance once again when she deliver's her presidential address next week in San Francisco.
Read More
 

The Protein Treasure Hunt
Bio-IT World | Dr Peter Hoffman's research group is using mass spectrometry to create high-resolution images of
proteins in archived tumour samples to help identify new diagnostic markers for cancer. Read More
 

ELSEWHERE IN THE NEWS 

High School Student Wins Science Prize
Huffington Post | 17-year-old Angela Zhang created a nanoparticle that can detect cancer cells, eradicate the
cancer cells and then monitor the treatment response. Read More
 

Secure Genomics in the Cloud
SmartPlanet | Scott Megill, CIO for the Coriell Institute for Medical Research, and Dan Pelino, General Manager
of IBM's Global Healthcare & Life Sciences Industry group, offer up the case for putting genomic data in the cloud.
Read More
 

Bayer Purchases Cloud App to Analyze Genomic Data
News Brief | Bayer HealthCare Pharmaceuticals has purchased a new cloud computing application to analyze and
visualize multi-dimensional genomics data: OncoGenomics Explorer, a software solution developed by MediSapiens.
Read More
 

Expensive Gene Therapy Approved in Europe
Reuters | Europe has approved an expensive gene therapy. Glybera treats the genetic disorder lipoprotein lipase
deficiency (LPLD) and will cost around 1.2 million euros ($1.6 million) per patient. Read More
 

Watson Learns Medicine
Fast Company | IBM's Watson computer is learning medicine. Through a series of apps and guidance by real
oncologists, the computer is practicing diagnoses and storing new disease facts in its database. Read More
 

Amazon Web Services Outage Postmortem
Computerworld | Last week's AWS outage drew myriad responses and placed blame, but it was an inevitable occurance.
The outage started small, but snowballed into a 12-hour event. Read More 
 

1000 Genomes Project Publishes Inventory of Human Genetic Variation
The Guardian | Scientists with the $1,000 Genomes Project have published the full genetic sequences of more than
1,000 people from 14 countries, creating the most complete inventory of the millions of variations between people's
DNA sequences ever assembled. The resource will shed light on the genetic roots of complex diseases, as well as
informing studies of human evolution. Read More