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This Week in Bio-IT World 

Physician Scientist Robert Darnell Named Scientific Director of New York Genome Center
Bio-IT World  | It took the better part of a year for the New York Genome Center (NYGC) to identify and recruit its first scientific director, but the search is finally over. The NYGC has appointed Robert Darnell, a Rockefeller University physician-scientist and Howard Hughes Medical Institute (HHMI) Investigator, as president and scientific director. Read More 

GPUs Model Maturation of HIV
Bio-IT World | Thanks to a distributed computing platform of NVIDIA GPUs, bioinformaticians at IMIM (Hospital del Mar Medical Research Institute) and UPF (Pompeu Fabra University) have used molecular simulation to explain a specific step in the maturation of HIV. The results were published in the most recent issue of PNAS.  Read More  

Adaptive Study Design May Become Survival Tactic
Bio-IT World | In the not-so-distant future, the pharmaceutical industry will need to move away from serendipity and its “blockbuster” drug development approach to become a service-based business specializing in patient-specific therapeutics delivering desired outcomes at the desired price. Clinical trials, of necessity, will be re-engineered to reflect real-world circumstances and turn adaptive study programs into a competitive advantage. Practicing clinicians will be dissuaded from using high-cost medicines and more actively participate in modeling and simulation exercises to help get better products to patients sooner. Read More 

Randy Scott: Bringing Metcalfe’s Law to Genomic Medicine
Bio-IT World | BOSTON—Receiving the 2012 Leadership in Personalized Medicine Award from the Personalized Medicine Coalition (PMC), Randy Scott reflected on his success as the founder and former CEO of Genomic Health, but also looked ahead to new opportunities with his latest venture, InVitae Corporation.  Read More 

Curing Cancer By Throwing Spaghetti At The Wall
Bio-IT World | The Skeptical Outsider | You know scientists are getting desperate when National Cancer Institute (NCI) researchers publicly boast that their approach is not limited to the realm of rational behavior. Heck, as long as funding is infinite, why not keep going back to re-drill the same dry holes hoping dumb luck will produce a gusher? Read More 

Numis Reiterates $2 Billion Valuation for Oxford Nanopore
Bio-IT World | An analyst with Numis Securities in London has reiterated a $2-billion valuation for Oxford Nanopore, even before the sequencing company has commercially launched, based on its assessment of the medical market and an evaluation of one of the British sequencing company’s major investors, the publicly traded IP Group. Read More 

Leading Big Data Company Appistry Joins Genome Institute of Singapore to Accelerate Genomics in Asia
Bio-IT World | On the heels of Appistry’s announcement with the Broad Institute as distributor of the GATK, the high-performance computing company announces a research collaboration with the Genome Institute of Singapore. Read More 

The New Manhattan Project: Q&A with NYGC Scientific Director Robert Darnell
Bio-IT World | Rockefeller University physician scientist Robert Darnell, son of Lasker Award winner James Darnell, is the newly appointed scientific director of the New York Genome Center (NYGC). Darnell gives his first in-depth interview to Bio-IT World editor Kevin Davies on his reasons for taking the job and his initial goals for the high-profile center. Read More 


Sequencing Reveals Novel Mutations in Childhood Cancer
Science Codex | Researchers at the Children's Hospital of Philadelphia have identified mutations in two related genes involved in neuroblastoma. The work was published yesterday in Nature Genetics. Read More 

Flash Memory Gets Heat Shock Healing
BBC | Flash memory is fast, but it's long been known to have reliability issues after about 10,000 read/write cycles. Researchers in Taiwan have now shown that a 800C jolt of heat can "heal" the memory, making it good for up to 100 million cycles. Read More 

HHMI Names New Vice President, CSO
HHMI | The Trustees of the Howard Hughes Medical Institute have elected Professor Erin K. O’Shea, Ph.D., now a Howard Hughes Medical Institute investigator at Harvard University, as Vice President and Chief Scientific Officer. Read More 

Amazon Launches Redshift Data Warehouse
eWeek | Amazon Web Services launched a cloud data warehouse earlier in the week. Redshift is a petabyte-scale data warehouse service that provides a fast and powerful solution that increases the speed of query performance. Read More 

Stanford Launches Genomics Center
Stanford Daily | Stanford University is launching the Stanford Center for Computational, Evolutionary and Human Genomics. The Center will reportedly specialize in the analysis of big data with a smaller emphasis on lab work. Read More 

Making Use of Smarter, Richer Data
GEN | Getting the big data is the easy part, making sense of it is the challenge for life sciences. Guy Cavet, vice president of life sciences at Kaggle, a platform for data science competitions, argues for not just big data, but smarter use of rich data. Read More