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THIS WEEK IN BIO-IT WORLD 

Titan Tops Top500 List in Latest Supercomputer Rankings
Bio-IT World | Weighing in at an impressive 17.59 petaflops, the new Titan supercomputer at the Oak Ridge National Laboratory (ORNL) in Tennessee has claimed the top slot at the first attempt in the latest Top500 world supercomputing rankings published today. Read More 

Genomics News and Product Briefs
Bio-IT World | With the American Society of Human Genetics conference ongoing in San Francisco this week, there’s been a flood of genomics products and news, announced at the event and elsewhere. Read More 

American College of Medical Genetics and Genomics Condemns Gene Patent Monopolies
Bio-IT World | Yesterday, the American College of Medical Genetics and Genomics (ACMG) released an official position statement condemning gene patent monopolies that have allowed some to develop proprietary databases of the clinical meaning of the variants in particular genes. Read More 

Sequencing Reveals Gene Regulation in E. Coli
Bio-IT World | Eric Schadt and colleagues at Mount Sinai School of Medicine and Harvard Medical School have used single-molecule real-time (SMRT) DNA sequencing to determine mechanisms of gene regulation in the E. coli bacteria involved in the deadly outbreak in Germany in May-June 2011. Published online today in Nature Biotechnology, the findings provide novel insights on the role of epigenetic DNA base modifications in driving molecular processes of the E. coli strain. Read More 

Brigham and Women’s Team Wins Clinical Genome CLARITY Challenge
Bio-IT World | SAN FRANCISCO—A team of computational biologists and clinical geneticists from the Brigham and Women’s Hospital in Boston has won the inaugural CLARITY Challenge to identify and present the putative mutations underlying the rare disorders of three children or infants who have received care at Boston Children’s Hospital and had their full genomes sequenced. Read More 

ELSEWHERE IN THE NEWS 

Computational Approach Shows Links Between Schizophrenia, Autism Gene Networks
Zee News | Using a sophisticated approach, researchers at the Department of Biomedical Informatics, the Center for Computational Biology and Bioinformatics, and the Columbia Initiative in Systems Biology at Columbia University Medical Center showed linkages between gene mutations associated with schizophrenia and autism. Read More 

FDA Releases New IT Strategic Plan
FDA Blog | Eric Perakslis, FDA’s Chief Information Officer and Chief Scientist for Informatics, reveals the FDA’s new FDA Information Management Strategic Plan this morning in a blog. There is still much to be done to modernize information technology at FDA, Perakslis says. Read More 

Interpretation and Assembly: New and Needed in Genomics
Nature Biotechnology | The biggest challenges in genomics now lie in interpretation and assembly. There's been a lot of progress, but there's also more to go. Ten experts discuss the advances and the needs to manage the millions of genomes soon to be sequenced. Read More 

Cray Acquires Appro for Cluster Computing, Increases I/O for New Line
Bio-IT World Roundup | Cray has signed an agreement to acquire Appro International for $25 million to create a cluster business. The company also discussed a new interconnect, Aries, that will feature a new routing topology that together promise to dramatically improve internal bandwidth. Read More