Systems Biology - Tools, Strategies, and Companies Driving Integrative Biology 


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Wednesday, April 16, 2008 | | Archives | Advertising | Your Account | CHI Conferences | Subscribe |
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We invite your comments and feedback for this edition of Systems Biology.
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Q&A: GNS: Building a "SNPs-to-Outcomes" Engine 
FDA: Let the Hiring Begin
Systems Biology Track Highlights Beyond Genome

Briefs from the Systems Biology Community

Webcast: Sequence Analysis; Genetic Variation (SNPs) 

Executive Q&A
GNS: Building a "SNPs-to-Outcomes" Engine

By John Russell

Personal and consumer genomics are boiling right now. The excitement, fueled by the plummeting costs of DNA sequencing and the rise of companies like 23andMe, feels tangibly different than many earlier biotech trends. It feels more concrete as if, for good or ill, something interesting and vast is about to happen. It's easy to imagine a raucous Wild West period during which traditional therapeutics, nutriceuticals, and "lifestyle" applications create a boisterous, buyer-beware marketplace and stir regulatory confusion.

Colin HillYet sifting through the coming data flood and connecting the dots in ways that accurately predict SNPs-to-outcomes remains a huge challenge. Gene Network Sciences CEO Colin Hill says flatly, "GNS is gunning to be the first group that really breaks this open, by having a scalable, supercomputer-driven automated platform that can turn that raw data into discoveries of the key SNPs driving the outcomes." Read more.


FDA: Let the Hiring Begin

FDA has been busy of late. Last week, Commissioner Andrew von Eschenbach announced the appointment of Frank M. Torti, Principal Deputy Commissioner and first Chief Scientist. This is a newly created position resulted from the Food and Drug Administration Amendments Act of 2007.

"As Chief Scientist and a member of the agency's senior leadership team, Dr. Torti will support the launch of the FDA Fellowship Program, which has the potential to attract up to 2,000 professionals of varying disciplines for a two-year training program," according to the FDA statement. "As well, the new office will work to ensure the quality and regulatory focus of the intramural research programs of the agency, and place special emphasis on the importance of clinical research trials that are a part of the foundation of the FDA's regulatory structure." Read more.


Systems Biology Highlights "Beyond Genome" Conference

When and what can systems biology practically deliver? One track at CHI's multi-meeting Beyond Genome, being held June 8-11 in San Francisco, will attempt to tease out answers to this question. The Applying Systems Biology portion will bring together leaders from around the world to present case studies.

This meeting will feature a comprehensive focus on Collaboration, including international projects for modeling the immune system.  Along with data and project results, experts will address logistical issues in an interactive panel discussion on collaborating across areas of expertise, lingo and national borders. The second portion of the meeting - Abstraction -- will look at new tools and explore the journey from wet lab to dry lab in light of technological breakthroughs, including an in-depth session focused on Gene Therapy.

Other meetings taking place at Beyond Genome examine RNA Interference, Personal Medicine, and Targeting Gene Therapy. More on the conference.

Briefs from the Systems Biology Community
  • Entelos reports '07 results; wins diabetes lab patent
  • Albert-Ludwigs University licenses Ariadne tools
  • PerkinElmer strikes deal with Cerep 
  • David Haussler honored by ISCB 
  • Screener 5.5 debuts
  • Compaq founder donates $18M to Caltech
  • Simcyp 8.0 handles more formulations
  • Novartis completes renal biomarker CRADA
  • ISC launches the parallel lounge blog for HPC
  • Ingenuity hits CRADA milestone; expands Pfizer deal
  • Takeda joins the HRP Initiative
  • Compugen signs agreement with Biosite 
  • Lipomics launches biomarker validation effort
  • Scripps joins MetaMiner Cardiac Consortium...Read full stories.


Mayo Clinic – Job #19191 - Unit Head – IT
Location:  Rochester, MN.  Oversee software development and support for research and operational activities for Health Sciences Research and Nursing Research departments. Recruit, manage, and mentor IT personnel; provide budget administration, client/vendor management, strategic planning and project coordination, planning, and estimating. Qualifications:  BS degree in computer science or similar field (master’s in computer science, management or health/clinical informatics desirable), and 6+ years’ professional IT.  Apply online at:

Mayo Clinic – Job #19178- Unit Head – IT
Location:  Rochester, MN.  Responsible for project coordination, planning and estimating, as well as budget administration, client/vendor management and strategic planning; plus coordinating technical resources that support research projects, journal publications, grant/contract preparation and scholarly activities. Qualifications: BS degree in computer science or a related field plus 6+ years’ IT experience.  Apply online at:

Titian Software - US Support Engineer
Become a key member of our Support staff by providing “best in class” services to our customers. Investigate, diagnose, resolve, and be responsible for resolution of customer support issues and liaise with our UK Software Development team to suggest, request and perform code and product changes based on field experience. For more information and to apply: 

Lilly Singapore Center for Drug Discovery (LSCDD) - Associate Director of Informatics,
Lead and mentor a strong team for the Bioinformatics group at the Integrative Computational Sciences (ICS) department at LSCDD towards the development of novel algorithms, data analysis methods and software tools for drug discovery. Work closely with the Software Engineering group at ICS, and collaborate with the Discovery IT organization in Europe and USA. For additional information, or to apply visit:

Lilly Singapore Center for Drug Discovery (LSCDD)- Senior Bioinformatics Scientist,Contribute to the development of novel algorithms, data analysis methods and software tools for drug discovery as part of the Integrative Computational Sciences (ICS) department at LSCDD.  Work closely with informatics and software engineering peers at ICS, and collaborate with the Discovery IT organization in Europe and USA. The successful candidate will offer hands-on insight and expertise in tailored therapeutic informatics and statistical analyses at the post-genomic era. For additional information, or to apply visit: LSCDD   

Lilly Singapore Center for Drug Discovery(LSCDD) -Senior Software Engineer,
Join a strong team of software engineers in our Integrative Computational Sciences (ICS) at LSCDD. Collaborate with, and help develop integrated applications to process and visualize data from cutting-edge technologies used by scientists at Lilly Research Labs (LRL) and the Drug Discovery Research (DDR) teams. The Software Engineering team provides computational tools and tailored software solutions that enable the global effort of Tailored Therapeutics; ‘The Right Drug, at The Right Dose for The Right Patient at The Right Time'. For additional information, or to apply visit:

Agilent Technologies-Asia Pacific - Job Requisition: 2021927
Job Title :   Application Engineer and Implementation Specialist for Lab Informatics Platform
Location(s) :  Bangalore, India.  Project management: small to large scale implementations, including integration/ validation of Agilent’s software platform.  Manage assigned customer account relationship, customer satisfaction and education of future Agilent plans.  On time and on budget implementation, focus Pharma, Petro and Chemical markets.  Qualifications:  BS/’MS Degree in Computer Engineering, or other related discipline or equivalent. Apply 

Agilent Technologies-Asia Pacific - Job Requisition:2021658, Job Title : Product Specialist – Laboratory Informatics Location(s) :  Bangalore, India.  Proactively understand customer needs and identify solutions to actively create business opportunities.  Manage a complex, enterprise solution sale with long sales cycle.  Develop approaches to achieve quota strategies.  Lead coordinated projects across organizations.  Solve complex broad range of problems.  Qualifications:  BS/MS Degree in Sciences, Engineering, Computer or equivalent plus 5 to 8 years work experience. Apply  

More Life Science Jobs ~ Add a Job Listing



Med-e-Tel, The International Educational and Networking Forum for eHealth, Telemedicine and Health ICT, 16-18 April in Luxembourg. 

Best Practices Awards Program -- April 29, 2008, Boston, MA 

The 1st Symposium on Protein Tomography -- May 1, 2008, Boston, MA

InforSense Translational Research Symposium, May 2,2008, Boston, MA 

Put MIT to work for you - ASP Info Session May 6,  Cambridge,MA 
The Post-Approval Summit  May 14-15, 2008, The Conference Center, Harvard Medical School, Boston, MA 

TEPR 2008 -- May 17-21, 2008 Ft. Lauderdale,FL 

EMC World 2008, May 19-22, 2008, Las Vegas,NV 

GOT Summit: Getting Optimized Tools for Diagnostics - May 19-21, 2008, Boston,MA

To have your event featured here, contact Lynn Cloonan for more information.

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SGI's Meeting Today’s Computational Needs for Science

The quest to better understand disease mechanisms and find new treatments is driven by new laboratory technologies and ever-more sophisticated modeling and simulation efforts. As such, life sciences R&D investigations increasingly are relying on more powerful computing resources. The challenge is how to accommodate the broad mix of applications.
Addressing this issue, this paper produced by the Bio-IT World Custom Publishing Group discusses a new SGI Hybrid Computing Environment approach. It optimally uses shared memory systems, multi-processor clusters, and FPGAs to accelerate computational workflows. Download This Free Paper 

SGI's Supercharging Proteomics Discovery

The deeper study of proteins and their interactions can reveal scientific information once considered nearly untouchable to scientists and researchers. Today, unprecedented advancements in computing power are enabling the creation of mounds of proteomic based data along with the accompanying bottlenecks data can create.  Rather than just “simplify the experiment” to fit the computational resources an alternative is now available with the SGI Proteomics Appliance. This complimentary white paper, produced by the Bio-IT World Custom Publishing Group, looks at ways to use the Proteomic Appliance to handle the most intensive proteomics computing tasks facing science today. Download This Free Paper

To have your white paper featured here, contact Lynn Cloonan for more information.


NEW! Life Science Webcasts from Bio-IT World and Cambridge Healthtech Media Group

Life Science Webcasts

Bio-IT World proudly introduces Life Science Webcasts -- a series of informal conversations with leading researchers and executives in the bio-IT and biopharma arena. This week, Dr. Samuel Levy, (senior scientist, Human Genomic Medicine, J. Craig Venter Institute) discusses 'Sequencing of the first diploid human genome sequence-that of Craig Venter' with Bio-IT World's Kevin Davies.

View the Webcast Now



Genstruct Adapts for Today's Challenges
March 19, 2008

Inside Strand Life Sciences
Feb. 14, 2008

India Is Connexios' Competitive Advantage
Jan. 16, 2008

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Cambridge Healthtech InstitutePublished by Cambridge Healthtech Media Group, division of CHI, Copyright © 2008; All rights reserved. Systems Biology may not be reproduced, electronically or in print, by any means, mechanical or electronic, in whole or in part, without written permission of Cambridge Healthtech Media Group, 250 First Ave., Suite 300, Needham, MA, 02494. 
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