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We invite your comments and feedback for this edition of Predictive Biomedicine.
 
John Russell
Executive Editor

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IN THIS ISSUE 
Letter: Modeling is Powerful BUT has Far to Go 
Survey Results: Taking Steps to Weather the Economic Storm 
Web Portal Aids Teamwork, Workflow of Cystic Fibrosis Research 
Pfizer's BBC Brings Fresh Perspective to Targets 
Short News & Analysis 
 

Letter to Editor
Modeling is Powerful BUT has Far to Go

[Editor’s Note: Many readers wrote to comment on my recent article, Modeling & Simulation Still Need a Push. One thoughtful and extensive response came from Frank Tobin, former head of a modeling initiative at GSK and now the chief computation officer for start-up, Strategic Medicine. He suggests advancing modeling inside pharma is complicated, identifies key obstacles yet to be overcome, and agues the process won’t be rushed unduly. His letter follows.] 

By Frank Tobin 

I read the recent article on modeling and simulation with interest. I'd like to give some perspectives after having run the Scientific Computing and Mathematical Modeling department at GlaxoSmithKline (GSK) for many years and after having used modeling for many different kinds of biopharmaceutical problems. My department is gone now, dissolved in one of the endless rounds of downsizing so trendy these days. More...

 

Survey
Taking Steps to Weather the Economic Storm

By John Russell

Predictive Biomedicine conducted a survey of technology providers to get their perspectives on running their companies in difficult times; on what their customers are seeking, and on whether the downturn would be a net plus or minus in prompting adoption of advanced computational tools. Some paint optimistic pictures while others say soberly the economic turmoil will test their survival skills.
We posed five broad questions. More...

 

Clinical Trials
Web Portal Aids Teamwork, Workflow of Cystic Fibrosis Research

By Deborah Borfitz

A web portal, recently rebuilt on Microsoft’s popular SharePoint platform, is being used to streamline the review of cystic fibrosis (CF) clinical trial protocols and facilitate collaboration. More...

 
 

Top Story Last Issue
Pfizer’s BBC Brings Fresh Perspective to Targets

Start with a person who should be sick but isn’t. Use DNA variation to hunt for broken genes that are keeping this person well. Set up a vigorous hypothesis generation and killing machine to mercilessly and quickly winnow through the options (no favored children allowed). Find and make drugs informed by the rare surviving hypothesis and race them through POC. More...

 

Short News & Analysis

(Click here for full briefs)

GenoLogics Wins JBEI Deal 
The Joint BioEnergy Institute (JBEI) of U.S. DOE will deploy GenoLogics lab and integrated data management solution for multiple sciences..
  
Euro Science Foundation Lays Out Sys Bio Plan
Crucial breakthroughs in the treatment of many common diseases such as diabetes and Parkinson's could be achieved by harnessing a powerful scientific approach called systems biology..

Test Handles Paraffin-Embedded Specimens
Pathwork Diagnostics launched a new version of its Tissue of Origin Test that can analyze formalin-fixed..

InforSense Founder Takes New Role
Yike Guo, InforSense founder, will transition from CEO to become Chief Technology Officer..

New Genotype Offering from Illumina
Illumina launched the Infinium HD (High Density) iSelect Custom Genotyping solution..

Is Warfarin Genotype Testing Cost-effective?
A recent study in Annals of Internal Medicine..

(Click here for full briefs

 

LIFE SCIENCE JOBS

Manager, Scientific Computing & Programming
Lead SAIC-Frederick, Inc.’s Bioinformatics & Analysis Group in developing & maintaining informatics pipelines for generation/analysis of dense genotyping & next-generation sequencing data. Required:  MS or equiv.  5 yrs related experience.  Knowledge of programming/software development, high performance computing, bioinformatics, project management. Visit www.saic-frederick.com - #130019.

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FEATURED EVENTS

The Association for Laboratory Automation (ALA) presents LabAutomation2009, January 24-28, in Palm Springs, CA. 

Immunogenicity for Biotechnology - January 26-27,2009

Health 3.0: Next Online Generation - January 26-28,2009 

Meeting the Challenges of Global Clinical Supply Chain Management,
 January 27th, 2009 

The BIO IT Coalition -
 
January 28, 2009 

Electronic Laboratory Notebooks - 28th - 29th, January 2009, Copthorne Tara Hotel, London, United Kingdom

TEPR+ 2009 - Feb 1-5, 2009 | Palm Springs, CA

You May Not Know What You Don't Know About Managing Your Trials, February 5th, 2009 

ABRF- 2009/Application and Optimization of Existing and Emerging Biotechnologies -  February 7-10, 2009

36th Annual Postgraduate Course in Clinical Pharmacology, Drug Development, & Regulation, February 9-13, 2009

The World Health Care Congress 2nd Annual Leadership Summit on Consumer Connectivity & Web Empowerment | February 23 – 24, 2009-
Carlsbad, CA 

16th International Molecular Medicine Tri-Conference -
February 25-27, 2009 

Electronic Data in Clinical Trials  March 11-12, 2009 – 
Miami, FL 

BIO IT Coalition's 8th annual Conference -
 
April 22, 2009 

Bio-IT World Conference & Expo – April 27-29, 2009  

Barnett Educational 
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FEATURED CONTENT

Integrated Software Approach to Streamline Method Development Workflow
by Waters

Traditional chromatography method development evaluates numerous chromatographic variables that may include selection of the column, solvent, flow rate, etc. This application note demonstrates an integrated approach to capturing and storing separation related reports during chromatography method development. Download now

Visit HP’s Extreme Storage Knowledge Center 

To find informative, complimentary case studies, white papers, videos, product information and more. You will learn about:  the challenges of unstructured storage and how to manage both cost-effectively and efficiently; case studies of data storage challenges that translate across pharmaceutical and biotech companies today; systems that manage vast amounts of data with simple deployment, unified management, and extreme scalability at an exceptionally low price; viable solutions for life sciences data management and growing storage demands. You may also take our virtual product tour and see the storage unit from inside out. 

eClinical Visions—Clinical Trial Management: Enabling Operational Efficiency

The report examines the growing importance of the clinical trial management system (CTMS) in an increasingly electronic world. There are mounting pressures on pharmaceutical firms to carry out larger and more complex trials in global locations, yet they must guarantee an even higher level of safety and accountability. Four thought leaders from diverse areas of healthcare present their views and experiences of CTMS in this comprehensive review.for more information click here

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Personalized Genetics: Advancements and Driving Change
Linda Avey, co-founder of 23andMe, delivers her keynote at the 2008 Bio-IT World Conference & Expo in Boston, April 30, 2008.
View the webcast.

The Future of Personal Genomics
A distinguished panel of personal genomics experts discuss the future of personal genomics at the 2008 Bio-IT World Conference & Expo in Boston, April 30, 2008.  They include Dietrich Stephan (co-founder, Navigenics); George Church (Harvard Medical School); Jeff Drazen (editor-in-chief, New England Journal Medicine); Fred Ledley (Bentley College); John Halamka (CIO, Harvard Medical School); and Linda Avey (23andMe). Bio-IT World Editor-in-Chief Kevin Davies moderates the discussion.
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Cambridge Healthtech InstitutePublished by Cambridge Healthtech Media Group, division of CHI, Copyright © 2008; All rights reserved. Predictive Biomedicine may not be reproduced, electronically or in print, by any means, mechanical or electronic, in whole or in part, without written permission of Cambridge Healthtech Media Group, 250 First Ave., Suite 300, Needham, MA, 02494. 
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