Predictive Biomedicine -- Informatics tools and strategies driving decisions 

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Microsoft Funded Research Hones in on Sys Bio Platform 
"Dumb Monkey" Wins SCDM Innovation Award 
Modeling is Powerful BUT Has Far to Go
Short News & Analysis 

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CoSBi Update
Microsoft Funded Research Hones in on Sys Bio Platform

By John Russell

Using computers to model living systems and to make useful predictions about their behavior is a holy grail pursued by many; yet there are far fewer seeking to go in the reverse direction and infer principles from living systems to improve computer science. Corrado Priami, president and CEO of the Centre for Computational and Systems Biology (CoSBi), a partnership between Microsoft, the Italian Government and University of Trento, is hoping to do both.

Formed just three years ago, CoSBi has grown steadily. Today it has about 25 researchers drawn from many disciplines (physics, chemistry, biology, etc). What's more, CoSBi has already developed a number of freely available prototype tools and is actively using the scientific community to refine its technology. An early version of the platform has made novel in silico predictions about gene transfer mechanisms which University of Trento researchers have taken into the wet lab to try to validate. 

If all goes well, says Priami, they will publish the results on the gene transfer work. More recently, Priami has written a short paper, Algorithmic Systems Biology, An Opportunity for Computer Science, which will be published in Communications of ACM (Association for Computing Machinery) in June 2009. The work sketches many of Priami's ideas on how computer science can be brought to bear on biology and vice versa. More...


Clinical Trials
"Dumb Monkey" Wins SCDM Innovation Award

By Ann Neuer

The Society for Clinical Data Management (SCDM) awards its Data Driven Innovation Award to a vendor/sponsor team for excellence in the advancement of clinical data management. The 2008 award went to Arrowhead Electronic Healthcare and Bayer HealthCare Pharmaceuticals for their innovation dubbed the "Dumb Monkey", a catchy name for an electronic patient reported outcomes (ePRO) automated testing and documentation. More...


Top Story Last Issue
Modeling is Powerful BUT Has Far to Go

By Frank Tobin

I read the recent article on modeling and simulation with interest. I'd like to give some perspectives after having run the Scientific Computing and Mathematical Modeling department at GlaxoSmithKline (GSK) for many years and after having used modeling for many different kinds of biopharmaceutical problems. My department is gone now, dissolved in one of the endless rounds of downsizing so trendy these days. More...


Short News & Analysis

(Click here for full briefs)

NIH Launches Three Informatics Pilots to Aid Translational Research
The three contracts are intended to improve informatics support for researchers conducting small-to medium-sized clinical..

An Open Access Database of GWA Results
Researchers Andrew Johnson and Christopher O'Donnell report collecting, "results from 118 GWAS articles into a database"..

Rewrite the Textbooks: Transcription is Bidirectional
EMBL researchers unravelled how yeast generates its transcripts and have come a step closer to understanding their function..

Ingenuity and Sigma-Aldrich Team Up on Portal
The two companies launched Your Favorite Gene, a Web-based biological search portal for exploring dynamic gene-based content..

IBM Pushes Cloud Computing Initiative
IBM announced it is working with six universities to leverage IBM Blue Cloud solutions to speed up projects and research..

Entelos Inks GSK Deal
GlaxoSmithKline signed an agreement to use Entelos' Hematopoeisis PhysioLab platform..

Genedata and Roche Extend Proteomics Collaboration
Genedata announced a three-year license extension with Roche for the Refiner MS module..

You've Got Email -- A Human Genome
A new report describes a method of compressing a whole human genome sequence into a file sufficiently small to..

Genomatix Joins Illumina-Connect Program
Genomatix joined the Illumina-Connect program working to develop new tools and applications for Illumina-generated data..

TCAG deploys Genologics LIMS
The Centre for Applied Genomics at The Hospital for Sick Children is deploying Genologics' LIMS across multiple facilities..

LabVantage Ehances Links to SAP ERP
LabVantage enhancing the certified integration of LabVantage Sapphire LIMS..

AccelerEyes Launches GPU Engine for MATLAB
HPCWire report the nascent GPGPU computing world received another boost today with the commercial release of Jacket..

Merck Poaches Star Cancer Specialist from Harvard
Obama isn't the only one stealing talent from Harvard. Merck has bagged D. Gary Gilliland..

UCLA Tool Predicts How a Chemotherapy Drug Will Work
UCLA scientists have tested a non-invasive approach that may allow doctors to evaluate a tumor's response to a drug before..

(Click here for full briefs)



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ABRF- 2009/Application and Optimization of Existing and Emerging Biotechnologies -  February 7-10, 2009

36th Annual Postgraduate Course in Clinical Pharmacology, Drug Development, & Regulation, February 9-13, 2009

Examining the Impact of the eCTD on the Regulatory Submissions Process, February 17, 2009

The World Health Care Congress 2nd Annual Leadership Summit on Consumer Connectivity & Web Empowerment | February 23 - 24, 2009-
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16th International Molecular Medicine Tri-Conference -
February 25-27, 2009 

Electronic Data in Clinical Trials  March 11-12, 2009 - 
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BIO IT Coalition's 8th annual Conference -
April 22, 2009 

Bio-IT World Conference & Expo - April 27-29, 2009  

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Interoperability and Architecture for the Life Sciences Industry
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What it will take to gain industry consensus on interchange standards, and what organizations can do today to optimize their own information architectures.
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eClinical Visions' Clinical Trial Management: Enabling Operational Efficiency

The report examines the growing importance of the clinical trial management system (CTMS) in an increasingly electronic world. There are mounting pressures on pharmaceutical firms to carry out larger and more complex trials in global locations, yet they must guarantee an even higher level of safety and accountability. Four thought leaders from diverse areas of healthcare present their views and experiences of CTMS in this comprehensive review.for more information click here

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The Future of Personal Genomics
A distinguished panel of personal genomics experts discuss the future of personal genomics at the 2008 Bio-IT World Conference & Expo in Boston, April 30, 2008.  They include Dietrich Stephan (co-founder, Navigenics); George Church (Harvard Medical School); Jeff Drazen (editor-in-chief, New England Journal Medicine); Fred Ledley (Bentley College); John Halamka (CIO, Harvard Medical School); and Linda Avey (23andMe). Bio-IT World Editor-in-Chief Kevin Davies moderates the discussion.
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