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Cellumen: Chasing Cellular Systems Biology 
High Throughput Screening Retools for the Future 
Microsoft Funded Research Hones in on Sys Bio Platform 
Short News & Analysis

Cellumen: Chasing Cellular Systems Biology
By John Russell

Founded in 2004 and based in Pittsburgh, Cellumen is one of a small but growing number of biotechs working to use high content screening in cell-based assays to identify promising drug candidates and to red-flag troublesome tox-causing compounds. Better reagents, less expensive and improved scanners, advancing informatics and human cell handling techniques are all propelling the community forward.

It will be interesting to watch the march forward of imaging based methods. No less than Eugene Myers, inventor of BLAST and now concentrating informatics for imaging, has said he thinks the amount of imaging-based data will eventually overwhelm even the genomics data flood (See, "Imaging Informatics," Bio-IT World, Jan/Feb 2009). What sets Cellumen apart, says Don Taylor, director of marketing and son of Cellumen founder Donald Lansing Taylor, is its "cellular systems biology" approach. More...


High Throughput Screening Retools for the Future
By Vicki Glaser

February 16, 2009 | Has high-throughput screening (HTS) suffused drug discovery pipelines with "hits" of sufficient quality and quantity to warrant the millions of dollars invested in the technology since the mid-1990's? That debate has been raging for years. Anemic productivity, a surplus of me-too drugs, and costly and embarrassing late-stage and post-market failures continue to plague the pharmaceutical industry, bolstering critics of HTS who challenge its return on investment. But HTS is evolving. More...


Top Story Last Issue
Microsoft Funded Research Hones in on Sys Bio Platform

By John Russell

Using computers to model living systems and to make useful predictions about their behavior is a holy grail pursued by many; yet there are far fewer seeking to go in the reverse direction and infer principles from living systems to improve computer science. Corrado Priami, president and CEO of the Centre for Computational and Systems Biology (CoSBi), a partnership between Microsoft, the Italian Government and University of Trento, is hoping to do both. More...

 Short News & Analysis

(Click for full briefs)

Another Harvard Research Star Changes Constellations
Arizona State University's Biodesign Institute landed Harvard Medical School scientist Joshua LaBaer to launch a cutting-edge research lab..

Millipore Uses GeneGo Data in New Pathway Tool
Millipore licensed 250 manually curated pathway maps from GeneGo for use in Millipore's new Interactive Biological Pathway Tool..

ISB Develop Automated, High Throughput Microfluidic Platform 
Researchers at ISB and University of British Columbia report a new microfluidic platform for conducting live-cell experimentation that enables high throughput imaging and on-chip microenvironment manipulation..

Euro Consortium Targets Plasma Biomarker Platfrom
The three-year project, called Proactive, will be coordinated by Olink Bioscience of Uppsala, Sweden..

BioImagene Receives FDA Clearance for PATHIAM
BioImagene received FDA 510(K) clearance for PATHIAM System with iScan for assessment of HER2/neu immunohistochemistry tests..

HHMI Scientists Develop New Approach to Protein Profiling
Jonathan Weissman’s new technology, called ribosome profiling, is more precise in identifying which proteins..

Drew Endy Calls for National Synthetic Biology Initiative
Stanford researcher Drew Endy argued the US needs a national initiative to support and encourage synthetic biology at the AAAS meeting..

Metabolon Work on Prostrate Cancer Progression Biomarkers
Metabolon's biochemical profiling has been used to identify biomarkers indicative of prostate cancer progression. Results of the study, conducted with researchers at the University of Michigan, were published in..

SciQuest Partrners with Ceiba
The companies say partnership will enable life sciences organizations to enhance their investment in enterprise resource planning (ERP)..

Thomson Reuters Launches Liquent PublishPerfect
Thomson Reuters introduced Liquent PublishPerfect, an enterprise publishing product that enables the efficient and compliant publishing..

Organisms Are More Than the Sum of Their Genes
John Yin of the University of Wisconsin-Madison developed computer models a simple virus to show that genes alone do not make an organism..

(Click here for full briefs)



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Exploring Next-Generation Sequencing
Bio-IT World Editor-in-Chief Kevin Davies interviews BGI's Laurie Goodman on the sequencing of the first Asian genome. View the webcast.

Personalized Genetics: Advancements and Driving Change
Linda Avey, co-founder of 23andMe, delivers her keynote at the 2008 Bio-IT World Conference & Expo in Boston, April 30, 2008.
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A distinguished panel of personal genomics experts discuss the future of personal genomics at the 2008 Bio-IT World Conference & Expo in Boston, April 30, 2008.  They include Dietrich Stephan (co-founder, Navigenics); George Church (Harvard Medical School); Jeff Drazen (editor-in-chief, New England Journal Medicine); Fred Ledley (Bentley College); John Halamka (CIO, Harvard Medical School); and Linda Avey (23andMe). Bio-IT World Editor-in-Chief Kevin Davies moderates the discussion.
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Cambridge Healthtech InstitutePublished by Cambridge Healthtech Media Group, division of CHI, Copyright © 2009; All rights reserved. Predictive Biomedicine may not be reproduced, electronically or in print, by any means, mechanical or electronic, in whole or in part, without written permission of Cambridge Healthtech Media Group, 250 First Ave., Suite 300, Needham, MA, 02494. 
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