Predictive Biomedicine -- Informatics tools and strategies driving decisions 

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John Russell
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DREAM Project Vision Expands 
Open Access Evangelist Wins 2009 Benjamin Franklin Award 
Video: Mark Boguski's Search for Resounding Health
Bio-IT World Expo Bound for Europe and Biotechnica
Monitoring Merrimack's Marathon Run
Short News & Analysis 

Prediction Learnings
DREAM Project Vision Expands

By John Russell

Almost exactly three years ago, organizers of DREAM -- Dialogue on Reverse Engineering Assessments and Methods -- sketched an ambitious plan help improve network predictions (inferences) in life science. The plans was to conduct a yearly DREAM challenge with blinded data sets; invite predictions; hold a conference to discuss results;  build a repository of better methods for network inferencing; and foster ongoing dialogue among computational biologists seeking to develop and use these tools.

So how's it going?

"I wonder that same thing every day," says Gustavo Stolovitzky, modestly, one of DREAM's founding organizers.

No doubt more could be done, but much has been done. Two sets of challenges, DREAM2 and DREAM3, have been conducted. Many of the lessons learned are contained in a text just published in March, *The Challenges of Systems Biology: Community Efforts to Harness Biological Complexity, representing work by two community efforts: the European Network of Excellence (ENFIN) and the DREAM project. It contains a section on DREAM2. More.


The Bourne Commendation: Open Access Evangelist Wins 2009 Benjamin Franklin Award
By Kevin Davies

Australian open-access evangelist Philip Bourne, a prolific computational biologist at the University of California San Diego (UCSD), has beaten out stiff competition to win the 2009 Benjamin Franklin Award.

The annual award, presented by the Bioinformatics Organization, is given to a scientist who epitomizes the open-source values espoused by the legendary inventor and statesman. Bourne will be presented with his award by Jeff Bizzaro, president of, at the 2009 Bio-IT World Conference & Expo in Boston on Tuesday, April 28. More.


Mark Boguski's Search for Resounding Health


Bio-IT World Expo Bound for Europe and Biotechnica

The Bio-IT World Conference will make its long-awaited European debut in Hannover, Germany, in conjunction with Biotechnica 2009 this October 6-8, thanks to a new partnership between Cambridge Healthtech Institute (CHI) and Deutsche Messe.

The initiative is the result of a new partnership between Bio-IT World’s parent organization, Cambridge Healthtech Institute (CHI), and Deutsche Messe, to organize and host two major life science conferences at Biotechnica 2009, which takes place in Hannover, Germany, October 6-8, 2009. The other conference being held is the Protein Engineering Summit (PEGS) Europe. More.


Top Story Last Issue
Monitoring Merrimack's Marathon Run
By John Russell

Merrimack Pharmaceuticals is frequently seen as a poster child for the systems biology approach to drug discovery. Founded in 2000, it has made few missteps. Last spring, Cambridge, Mass-based Merrimack had the good fortune to raise $65 million in a series F financing round before the economy soured. In July, the company's first compound developed using its systems biology approach, MM121 (oncology), entered Phase One. More.


Short News & Analysis

(Click For Full Briefs)

Dana-Farber Launches Computational Services Center 
The center will deliver analytical services and accelerate 'omics research..

GenoLogics Teams with Applied Biosystems
GenoLogics will provide an integrated lab and data management solution for the SOLiD System..

GNS Strikes Research Collaboration with M.D. Anderson
The deal is aimed at the rapid translation of DNA sequence and clinical data from patients with glioblastoma into breakthrough..

Codon Closing as Financing Dwindles
Codon Devices, a five-year-old Boston synthetic biology company co-founded by George Church and Drew Endy, is quietly shutting..

ISB Researchers New Powerful Algorithm
“Until recently, genetics has been practiced mainly as the study or identification of this gene or that gene..

MIT Develops Model for Protein Interaction
Many proteins have very similar structures, yet somehow they locate and interact with only their specific partner..

MDS/AB Launch New Mass Spec
Applied Biosystems and its mass spectrometry joint-venture partner, MDS Analytical Technologies introduced..

University of Michigan Installs Genomatrix Platform 
Genomatix reports the Informatics Core of the Center for Computational Medicine and Biology at Michigan..

Physiomics Announces License Agreement with Eli Lilly
Physiomics signed a license agreement with Eli Lilly for a custom version of its “ModelPlayer” for in silico simulations..

Lauffenburger Team Uses Fuzzy Logic to Model Cell Behavior
Living cells are bombarded with messages from the outside world -- hormones and other chemicals tell them to grow, migrate..

(Click For Full Briefs)



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To have your job openings featured here, contact Lynn Cloonan for more information.



Cloud Computing is changing Pharmaceutical IT - Free white paper

Managing Next-Generation Sequencing Data-Podcast!

LIMS for Enhanced Productivity

Novoseek, the biomedical search engine based in text mining technology.

Electronic Notebook: Streamline experimental IP; capture and re-use data; enhance collaboration. 

To have your product or service featured here, contact Lynn Cloonan  for more information.


Insight Pharma Reports

Direct-To-Consumer Genetic Testing: Business Prospects in the United States 
Author: Kathie L. Wrick, Ph.D 

Direct-To-Consumer Genetic Testing: Business Prospects in the United StatesGenetic testing has come a long way since the development of the first genetic test in 1963. According to NIH, almost 1,500 genetic tests are now in use. This report focuses on health-related decision making applications of DTC genetic tests and examines various components of this emerging business environment. Read more.



Bio-IT World Conference & Expo -- April 27-29, 2009  

BIO IT Coalition's 8th annual Conference - April 22, 2009 

Combining Technology and PK/PD Expertise to Optimize Drug Development: A New Era for Collaborative Environments in Translational Medicine- Wednesday, April 22nd

REGISTER TODAY, April 28-29, 2009, The Post-Approval Summit 

The 2009 BIO International Convention has you covered - May 18-21, 2009

Barnett Educational Services 

Cambridge Healthtech Events 

To have your event featured here, contact Lynn Cloonan for more information.

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Coherent IT Strategy for
Fast-Moving R&D
Sponsored by: Tessella 

Putting value on an IT strategy is easier with an end-to-end view, from target to market, of the cause and effect of good and bad information and decisions. This forges the essential link between science, information, IT and business funding of the IT investment. Download now 

Electronic Submissions
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In the time-consuming and costly battle to gain market share, faster time to market equals a competitive advantage for life sciences companies. Efficiencies in the product development cycle impact the bottom line. To succeed, companies must streamline the collaborative processes of creating, assembling, and delivering accurate, approvable electronic submissions. Adobe LiveCycle ES (Enterprise Suite) solutions help simplify the submission process, enabling life sciences companies to achieve earlier filing dates, greater accuracy and quality of data, and ultimately faster time to market.  Download Now

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To have your white paper featured here, contact Lynn Cloonan for more information.


NEW! Life Science Webcasts from Bio-IT World and Cambridge Healthtech Media Group

Life Science Webcasts

Modeling Caloric Restriction
Using their causal network modeling (CNM) platform, Renee Kenney and her team at Genstruct helped Sirtris Pharmaceuticals model how two of their SIRT1 compounds worked and show that one compound in particular is much more potent at mimicking caloric restriction than resveratrol, an active ingredient in red wine.
 View the webcast. 

Paul Bleicher, Looking Back at Phase Forward
After founding Phase Forward more than a decade ago and serving as Chairman until late last year, Paul Bleicher has had a prime perch from which to observe and drive change in the e-clinical industry. In this exclusive Life Sciences TV Webcast to mark his decision to step down as Chairman last last year, Bleicher looks back with Bio-IT World Editor Kevin Davies on a decade of achievement and hints at his next venture in the health care arena. View the webcast.

Exploring Next-Generation Sequencing
Bio-IT World Editor-in-Chief Kevin Davies interviews BGI's Laurie Goodman on the sequencing of the first Asian genome. View the webcast.


View the Predictive Biomedicine newsletter archives here.

Cambridge Healthtech InstitutePublished by Cambridge Healthtech Media Group, division of CHI, Copyright © 2009; All rights reserved. Predictive Biomedicine may not be reproduced, electronically or in print, by any means, mechanical or electronic, in whole or in part, without written permission of Cambridge Healthtech Media Group, 250 First Ave., Suite 300, Needham, MA, 02494. 
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