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We invite your comments and feedback for this edition of Predictive Biomedicine.
John Russell
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Biovista's Brand of In Silico Drug 'Discovery' 
Etrials Purchase Would Make BioClinica Number Three EDC Player 
Microsoft Launches Amalga Life Sciences
Short News & Analysis
Increase the pace of research

Biovista's Brand of In Silico Drug 'Discovery'
By John Russell

Many companes are seeking to build businesses around repositioning and de-risking drugs but mostly with limited success. Biovista will succeed, says co-founder and president Aris Persidis, because its in silico approach combines vastly diverse data and an expanded concept of mode of action to produce novel insights about known drugs.

"[By] this time next year we will have 20 of the most famous drugs out there under new use IP--we have 12 already--and the year after that it will be about 40 or 50. This is where we really think there is the potential to game-change the industry." More...

Accelerate the pace of new discoveries

Etrials Purchase Would Make BioClinica Number Three EDC Player
By Deb Borfitz

What reputable products and a succession of management teams couldn't do for etrials Worldwide its soon-to-be owner most likely can: boost stagnating sales and stem the red ink. The beleaguered clinical trials software company agreed to be acquired by cash-positive Bio-Imaging Technologies in a $10 million deal expected to consummate in mid-June, the publicly traded companies jointly announced on May 5.

Bio-Imaging Technologies entered the electronic data capture (EDC) business with last year's purchase of Phoenix Data Systems (PDS) and recently began doing business under the name BioClinica, says President and CEO Mark Weinstein. The addition of etrials doubles the client base for EDC to about 80 trial sponsors. More...


Top Story Last Issue
Microsoft Launches Amalga Life Sciences

By John Russell

Microsoft introduced Amalga Life Sciences this week at the annual Bio-IT World Conference & Exposition. Amalga LS is the next step in Microsoft's ambitious plan to create a single information highway and data aggregation/modeling platform -- Amalga -- that spans basic research, clinical trials, health care delivery, and consumer health information needs.

"We think of this as an information supply chain where information can flow in the right way, at the right time, and in the right context. Think of five broad categories of activities: collect, validate, store, analyze, and share. Amalga LS can navigate through this data and connect even dissimilar forms of data, such as biochemical data, EMR, pathway data, gene ontologies, expression data and so on," says Jim Karkanias, senior director of applied research, Microsoft Health Solutions Group. More...

 World Pharmaceutical Congress - June 9-11, 2009

Short News & Analysis

(Click for Full Briefs)

Entelos Shuffles Management; Karis, Blazei Exit 
Last week Entelos named Jim Neal as acting President and acting CEO..

Computational Analysis of H1N1 Mounted
A computational biology group led by Raul Rabadan is now analyzing recent sequences from samples in..

Applied Biosystems Launches Molecular Tools for Pathways 
AB introduced new tools for investigating the role of specific genes involved in more than 80 key biological pathways..

GNS Wins REFS Platform Patent
The patent, entitled "Systems and Methods for Inferring Biological Networks," and covers GNS's core model learning and..

Hopfield to Receive 2009 Rosenblatt Award from IEEE
John Hopfield will receive the award for his contributions to the understanding of information processing in biological systems..

BGM Launches Galectin-3 Website
Galectins are a unique class of proteins with a relatively high affinity for specific carbohydrate compounds..

Computers Helping Superbug Study
Researchers at Edinburgh University studied computer software which could help develop more effective antibiotic treatments..

(Click for Full Briefs)



Manager, Advanced IT Core(AITC) -Indiana University School of Medicine
Reports to Senior Manager for Life Sciences in Research Technologies. Requires coordination of AITC services, supervision of select R&D projects, external funding initiatives, partnering with key academic researchers, conducting relevant independent research, advising on new strategic technologies and facility designs, and development of training programs.
Qualifications Include:
* Master's Degree in Biology, Bioinformatics, or Informatics with medical research background.
* Five to seven years of related work and leadership experience.
* Expert knowledge of computational biology, particularly genomics, proteomics, research pipelines, data management, and analytical algorithms required.
Complete description, requirements and application can be found at:
Indiana University is an Affirmative Action/Equal Employment institution.

To have your job openings featured here, contact Lynn Cloonan for more information.



Make better IT decisions-free whitepaper

Secure Web Conferencing-Complimentary Webinar

Translational Research-Editorial Report

Cloud Computing is changing Pharmaceutical IT - Free white paper

Managing Next-Generation Sequencing Data-Podcast! 

LIMS for Enhanced Productivity 

Novoseek, the biomedical search engine based in text mining technology.

Free Electronic Notebook Webinar: Enhance workflow and collaboration. 

To have your product or service featured here, contact Lynn Cloonan for more information.


Insight Pharma Reports

Direct-To-Consumer Genetic Testing: Business Prospects in the United States 
Author: Kathie L. Wrick, Ph.D 

Direct-To-Consumer Genetic Testing: Business Prospects in the United StatesGenetic testing has come a long way since the development of the first genetic test in 1963. According to NIH, almost 1,500 genetic tests are now in use. This report focuses on health-related decision making applications of DTC genetic tests and examines various components of this emerging business environment. Read more.



The 2009 BIO International Convention has you covered - May 18-21, 2009

DIA 45th Annual Meeting, June 21-25, 2009, San Diego, CA

Barnett Educational Services 

Cambridge Healthtech Events 

To have your event featured here, contact Lynn Cloonan for more information.

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Leveraging Text-Mining 
Based Search to Navigate Biomedical Literature 
Sponsored by: Bioalma

With the amount of research data available today estimated at 18 million documents across more than 20,000 medical journals, it is more important than ever that students, researchers, professionals, doctors, and librarians have easy access to the latest research information available.Download the paper 

Translational Research Briefing ON Report
Sponsored by: GenoLogics

The varied collection of Bio-IT World articles and insights assembled in this Briefing ON examines:
The impact of integrating clinical data back into the research and development pipeline. Using information gathered from physical samples, databases, and clinical trials to benefit the design and performance of future research. Download the complimentary report 

Adobe Secure Web
Conferencing for Healthcare & Life Sciences
Sponsored by Adobe

From collaboration around new drug development and clinical trials to marketing new healthcare products and research, Web conferencing can dramatically save time and money while increasing productivity. In this comprehensive overview you will learn:
New ways to use web conferencing in the healthcare and life science industries for improving productivity and overall efficiency.
How to select a comprehensive, secure and easy to use Web conferencing platform that meets your compliance needs and provides support.
Effective strategies using Secure Web conferencing as a powerful tool for on-demand collaboration, mass communication, and resource conservation.
Register now and watch at your convenience.

To have your white paper featured here, contact Lynn Cloonan for more information.


NEW! Life Science Webcasts from Bio-IT World and Cambridge Healthtech Media Group
Life Science Webcasts
Boguski's Resounding Health
Mark Boguski is launching a new direct-to-consumer Internet search firm called Resounding Health and he tells Bio-IT World Editor, Kevin Davies, all about it. His goal is to create "value-adding process networks" to provide "the most cost-effective management of chronic diseases in the near future." When the Resounding Health "brain" achieves a critical mass of validated and important connections, "we will have in effect crowdsourced a revolutionary new, e-patient-friendly textbook of personalized medicine and customized care." View the webcast.

Open Source Models for Personalized Medicine
Through the company he founded, CollabRx, Jay "Marty" Tenenbaum aims to leverage the extraordinary untapped expertise and resources across the industry to empower individual patient health care through personalized research. View the webcast.

Modeling Caloric Restriction
Using their causal network modeling (CNM) platform, Renee Kenney and her team at Genstruct helped Sirtris Pharmaceuticals model how two of their SIRT1 compounds worked and show that one compound in particular is much more potent at mimicking caloric restriction than resveratrol, an active ingredient in red wine.
 View the webcast.

Paul Bleicher, Looking Back at Phase Forward
After founding Phase Forward more than a decade ago and serving as Chairman until late last year, Paul Bleicher has had a prime perch from which to observe and drive change in the e-clinical industry. In this exclusive Life Sciences TV Webcast to mark his decision to step down as Chairman last year, Bleicher looks back with Bio-IT World Editor Kevin Davies on a decade of achievement and hints at his next venture in the health care arena.
 View the webcast.


View the Predictive Biomedicine newsletter archives here.

Cambridge Healthtech InstitutePublished by Cambridge Healthtech Media Group, division of CHI, Copyright © 2009; All rights reserved. Predictive Biomedicine may not be reproduced, electronically or in print, by any means, mechanical or electronic, in whole or in part, without written permission of Cambridge Healthtech Media Group, 250 First Ave., Suite 300, Needham, MA, 02494. 
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