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What’s Wrong with Biomarkers?

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Breaking: Pacific Biosciences Nets Eric Schadt as Chief Scientific Officer
Network Biology 2.0 Symposium Attracts Prominent Lineup 
ORBIT: Aurora's Biorepository Could Become Nation's Largest 
Biovista's Unusual Brand of In Silico Drug Discovery 
Short News & Analysis
Strategic Resource Management

Breaking: Pacific Biosciences Nets Eric Schadt as Chief Scientific Officer
By Kevin Davies

Eric Schadt, the Merck biomathematician whose groundbreaking studies on disease pathways and genome data integration have drawn plaudits from the scientific community, is joining the next-generation sequencing company Pacific Biosciences as Chief Scientific Officer. Read more.


Network Biology 2.0 Symposium Attracts Prominent Lineup
By John Russell

The roster of speakers at last week's Network Biology 2.0 symposium, sponsored by Gene Network Sciences (GSN) and the Broad Institute and held at the Broad, featured some of the most influential people in systems biology and personalized medicine -- Jim Collins, George Church, Mark Boguski, and Peter Sorger to name but a few. Eric Schadt was scheduled but a last minute conflict caused a switch and he was ably stood in for by his former Merck/Rosetta colleague Jun Zhu. More.

Increase the pace of research

ORBIT: Aurora's Biorepository Could Become Nation's Largest
By Deb Borfitz

Aurora Health Care, a large not-for-profit system based in Milwaukee, WI, recently launched what is expected to become the nation's largest and most comprehensive biorepository. In a few years, it could trump the size of Iceland's bank of biological specimens providing genetic details on virtually its entire populace. More.


Top Story Last Issue
Biovista's Unusual Brand of In Silico Drug Discovery

By John Russell

Many companes are seeking to build businesses around repositioning and de-risking drugs but mostly with limited success. Biovista will succeed, says co-founder and president Aris Persidis, because its in silico approach combines vastly diverse data and an expanded concept of mode of action to produce novel insights about known drugs.

"[By] this time next year we will have 20 of the most famous drugs out there under new use IP--we have 12 already--and the year after that it will be about 40 or 50. This is where we really think there is the potential to game-change the industry," Persidis says. More.

 World Pharmaceutical Congress - June 9-11, 2009

Short News & Analysis

(Click for Full Briefs)

Compugen Reports Promising In Vivo Results
Compugen reported positive in-vivo results for CGEN-856 and CGEN-857, two novel peptide agonists of the MAS G-protein coupled receptor (GPCR) which the company discovered using its in silico platform. Recently studies demonstrated the cardioprotective and anti-hypertensive effects of these two product candidates, says Compugen..
Genetic Anti-Discrimination Law Takes Affect
A long-awaited federal law that shields people from genetic discrimination will planted its first layer of protection Thursday. The measure will prevent health insurers from denying coverage, adjusting premiums or otherwise discriminating based on genetic information, a term that includes family history.. 

Switzerland Grants $25M for Systems Biology Studies
The Swiss National Science Foundation has granted CHF27.5 million ($25 million) to fund several biomedical research and genomics and technology development grants focused on systems biology..

Ausubio to Use Genedata Biomarker Discovery Platform
Asubio Pharma, a wholly-owned subsidiary of Daiichi Sankyo, is using the Genedata Expressionist system to support their compound profiling and biomarker discovery process. "We were looking for a bioinformatics solution to manage a huge volume of DNA array data generated internally at Asubio as well as to integrate additional external molecular profiling data,” said Michinori Kadokura, associate senior researcher at Asubio.

NIH Grants $2M for Development of e-Microscope
The plan is to extend the capabilities of a powerful new imaging tool called the dynamic transmission electron microscope or DTEM. These instruments can snap 10 to 100 images per millionth of a second, while capturing details as small as 10 nanometers, or about four times the diameter of a DNA molecule.

Ingenuity Systems Releases IPA 7.5
The latest version of the software enables researchers to quickly integrate and understand multiple lines of experimental evidence from either publicly available or proprietary data sources.

Genego and Omicsoft Announce Integration
GeneGo and OmicSoft Corporation report the integration of the MetaCore pathway analysis platform with Array Studio..

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Manager, Scientific Computing & Programming (Bioinformatics Manager)
SAIC-Frederick, Inc
 has an exciting opportunity for a Manager, Scientific Computing & Programming - Core Genoytyping Facility in Gaithersburg, Maryland.  In this role, you will lead the Bioinformatics & Analysis Group.
Master’s or equivalent required.  PhD preferred. Six years experience in development of scientific programs in high-performance computing environment including five years supporting scientific research in computational chemistry, biology, or genetics, & two years supervisory experience.  View complete job posting & apply: Position #146945.

Manager, Advanced IT Core(AITC) -Indiana University School of Medicine
Reports to Senior Manager for Life Sciences in Research Technologies. Requires coordination of AITC services, supervision of select R&D projects, external funding initiatives, partnering with key academic researchers, conducting relevant independent research, advising on new strategic technologies and facility designs, and development of training programs.
Qualifications Include:
* Master's Degree in Biology, Bioinformatics, or Informatics with medical research background.
* Five to seven years of related work and leadership experience.
* Expert knowledge of computational biology, particularly genomics, proteomics, research pipelines, data management, and analytical algorithms required.
Complete description, requirements and application can be found at:
Indiana University is an Affirmative Action/Equal Employment institution.

To have your job openings featured here, contact Lynn Cloonan for more information.



Make better IT decisions-free whitepaper

Secure Web Conferencing-Complimentary Webinar

Translational Research-Editorial Report

Cloud Computing is changing Pharmaceutical IT - Free white paper

LIMS for Enhanced Productivity 

Novoseek, the biomedical search engine based in text mining technology.

Free Electronic Notebook Webinar: Enhance workflow and collaboration. 

To have your product or service featured here, contact Lynn Cloonan for more information.


Insight Pharma Reports

Direct-To-Consumer Genetic Testing: Business Prospects in the United States 
Author: Kathie L. Wrick, Ph.D 

Direct-To-Consumer Genetic Testing: Business Prospects in the United StatesGenetic testing has come a long way since the development of the first genetic test in 1963. According to NIH, almost 1,500 genetic tests are now in use. This report focuses on health-related decision making applications of DTC genetic tests and examines various components of this emerging business environment. Read more.



Advances in Oncology Drug Development: Linking Drug Response Phenotypes to Multiplex Molecular Signatures, Thursday, June 18th, 2009

DIA 45th Annual Meeting, June 21-25, 2009, San Diego, CA
Insight and Innovation: Novel Approaches to Safety Pharmacology and Toxicology in the 21st Century
 - Tuesday, June 23rd, 2009, Tuesday 30 June - Wednesday 1 July 2009, Virtual Event

Barnett Educational Services 

Cambridge Healthtech Events 

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Bio-IT World Europe
Bio-IT World Europe builds on the strong success of CHI's U.S. Bio-IT World Conference & Expo, which takes place in Boston each Spring.

We are pleased to announce the inaugural European event co-located with BIOTECHNICA, Europe's No. 1 event in Biotechnology and Life Sciences with a total of 16,000+ participants.

Bio-IT World Europe will continue uniting life sciences, pharmaceutical, and IT professionals to share ideas and innovation through networking and education.  

Conference Tracks include Hardware for the Life Sciences; Bioinformatics for Genomics; IT Software for the Life Sciences; and Data Integration and Knowledge Management. Download a conference brochure today.

What's Wrong with Biomarkers?What’s Wrong with Biomarkers?
Sponsored by: Definiens

The hype around biomarkers has reached such a fever pitch that it risks provoking a backlash among needed constituencies such as payers, physicians, and patients. No one doubts biomarkers' long-term value, but many obstacles remain, and that time still seems distant. Read this in-depth analysis in which distinguished experts examine biomarker challenges.Access the Paper

Protecting Intellectual Protecting Intellectual Property Property
Sponsored by: IDBS 

Intellectual property (IP) remains one of the most important assets of any commercial entity. Historically, paper has been used to establish, maintain and defend IP, but as industry becomes increasingly digital, new tools must be used to ensure IP protection. In this white paper we explore the issues facing patent creation and defense in the electronic age and discuss the tools and functionality required to protect innovation. Access the Paper 

Leveraging Text-Mining 
Based Search to Navigate Biomedical Literature 
Sponsored by: Bioalma 

With the amount of research data available today estimated at 18 million documents across more than 20,000 medical journals, it is more important than ever that students, researchers, professionals, doctors, and librarians have easy access to the latest research information available.Download the paper 

To have your white paper featured here, contact Lynn Cloonan for more information.


NEW! Life Science Webcasts from Bio-IT World and Cambridge Healthtech Media Group
Life Science Webcasts
Boguski's Resounding Health
Mark Boguski is launching a new direct-to-consumer Internet search firm called Resounding Health and he tells Bio-IT World Editor, Kevin Davies, all about it. His goal is to create "value-adding process networks" to provide "the most cost-effective management of chronic diseases in the near future." When the Resounding Health "brain" achieves a critical mass of validated and important connections, "we will have in effect crowdsourced a revolutionary new, e-patient-friendly textbook of personalized medicine and customized care." View the webcast.

Open Source Models for Personalized Medicine
Through the company he founded, CollabRx, Jay "Marty" Tenenbaum aims to leverage the extraordinary untapped expertise and resources across the industry to empower individual patient health care through personalized research. View the webcast. 

Modeling Caloric Restriction
Using their causal network modeling (CNM) platform, Renee Kenney and her team at Genstruct helped Sirtris Pharmaceuticals model how two of their SIRT1 compounds worked and show that one compound in particular is much more potent at mimicking caloric restriction than resveratrol, an active ingredient in red wine.
 View the webcast. 

Paul Bleicher, Looking Back at Phase Forward
After founding Phase Forward more than a decade ago and serving as Chairman until late last year, Paul Bleicher has had a prime perch from which to observe and drive change in the e-clinical industry. In this exclusive Life Sciences TV Webcast to mark his decision to step down as Chairman last year, Bleicher looks back with Bio-IT World Editor Kevin Davies on a decade of achievement and hints at his next venture in the health care arena.
 View the webcast.


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