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April 15, 2003 | U.S. and European companies in the lead-optimization business include startups and established names in the life sciences. Large pharmaceutical companies are starting to form tighter partnerships. But no industry-leading tool has yet been proven by peer-reviewed research to find drugs faster.
3-Dimensional Pharmaceuticals www.3dp.com
Recently acquired by Johnson & Johnson
Accelrys www.accelrys.com
Leading bio-, cheminformatics platform; IBM is a partner
Advanced Chemistry Development
www.acdlabs.co.uk
Powerful predictive algorithms, automated sample analysis
Argenta Discovery www.argentadiscovery.com
Roots were collaboration between Aventis, British academics
Arqule www.arqule.com
Pfizer recently acquired major stake in company
ComGenex www.comgenex.com
Hungarian company, doing research with NYC blood bank
Gene Logic www.genelogic.com
Roche licenses its customized gene expression database
GeneTrove www.genetrove.com
Celera, Abbott, Aventis, Johnson & Johnson are customers
Iconix Pharmaceuticals www.iconixpharm.com
Amersham, MDL, FDA have agreements with company
Inpharmatica www.inpharmatica.co.uk
Helping Chiron study ESTs for oncology drugs
Libraria www.libraria.com
Grant from National Institute of Standards and Technology
LION Bioscience www.lionbioscience.com
Deals with AstraZeneca, Bayer; data and tool integration
MDL Information Systems www.mdli.com
Founded in 1978; leading cheminformatics platform
Paradigm Genetics www.paradigmgenetics.com
NASDAQ considering delisting company at press time
Structural Bioinformatics www.strubix.com
Partner, investor Quest Diagnostics collaborating on one database
Symyx www.symyx.com
ExxonMobil, Merck, Lilly, others license chemical discovery tools
Tripos www.tripos.com
LeapFrog module uses receptor site for de novo ligand design
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