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April 15, 2003 | U.S. and European companies in the lead-optimization business include startups and established names in the life sciences. Large pharmaceutical companies are starting to form tighter partnerships. But no industry-leading tool has yet been proven by peer-reviewed research to find drugs faster.


3-Dimensional Pharmaceuticals www.3dp.com 
Recently acquired by Johnson & Johnson

Accelrys www.accelrys.com 
Leading bio-, cheminformatics platform; IBM is a partner

Advanced Chemistry Development 
www.acdlabs.co.uk 
Powerful predictive algorithms, automated sample analysis

Argenta Discovery www.argentadiscovery.com 
Roots were collaboration between Aventis, British academics

Arqule www.arqule.com 
Pfizer recently acquired major stake in company

ComGenex www.comgenex.com 
Hungarian company, doing research with NYC blood bank

Gene Logic www.genelogic.com 
Roche licenses its customized gene expression database

GeneTrove www.genetrove.com 
Celera, Abbott, Aventis, Johnson & Johnson are customers

Iconix Pharmaceuticals www.iconixpharm.com 
Amersham, MDL, FDA have agreements with company

Inpharmatica www.inpharmatica.co.uk 
Helping Chiron study ESTs for oncology drugs

Libraria www.libraria.com 
Grant from National Institute of Standards and Technology

LION Bioscience www.lionbioscience.com 
Deals with AstraZeneca, Bayer; data and tool integration

MDL Information Systems www.mdli.com 
Founded in 1978; leading cheminformatics platform

Paradigm Genetics www.paradigmgenetics.com 
NASDAQ considering delisting company at press time

Structural Bioinformatics www.strubix.com 
Partner, investor Quest Diagnostics collaborating on one database

Symyx www.symyx.com 
ExxonMobil, Merck, Lilly, others license chemical discovery tools

Tripos www.tripos.com 
LeapFrog module uses receptor site for de novo ligand design


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