Image Management and 21 CFR Part 11

By BIO-IT World

May 9, 2003 | Images and accompanying data are part of a drug approval submission to the FDA. 21 CFR Part 11 guidelines require that images from which data were extracted be stored and not altered in any way. A time-stamped audit trail must reveal what manipulations have been performed on the image, and reconstructing that path must be made clear to the FDA.

Managed storage is a must for images. After all, says Mike Esterman, senior information consultant at Lilly Research Laboratories, when it comes to 21 CFR Part 11, "After Y2K, we need something else to panic about." And there's another reason to consider image management seriously: "It's the law."

During a recent Webcast through Scimagix (scimagixevents.webex.com/scimagixevents), imaging analysts at Eli Lilly discussed the ins and outs of adhering to the federal guidelines:

What 21 CFR Part 11 covers

  • The FDA expects you to be able to verify where any data that might be submitted came from, what they are, and how they were processed

What to do 

  • Make sure the image is accurate, complete, uncompressed, and that all the metadata about the image have been preserved

How to do it

  • The image should be stored in the acquisition mode even if it is analyzed in a different mode
  • Store a reader along with the image to avoid media obsolescence
  • CDs and DVDs are preferable to tape

How long to do it 

  • The retention period could be considerable, so you need managed image storage
  • Ensure that the data are retrievable by keeping old software and hardware or migrating data to a new platform, and (re)training personnel on the usage of outdated systems



Back to The Sharper Image 


White Papers & Special Reports

Coupa white paper 92
10 Secrets to Recession-Proof Your Business
Sponsored by Coupa


Read this white paper to discover 10 strategies smart companies deploy to recession-proof their business.
Leaders generally face hard choices on how to mange a company during an economic downturn and
behave in one of three ways:
1) “The ostrich” - Preserve the status quo/hope for the best
2) “The bull in the china shop” - Blindly cut expenses across the board
3) “The fox” - Use the downturn to make your business more effective and position it for future growth

Learn how to behave “like a fox” and use a recession as a means to pounce on emerging trends.



SGI BriefingON image
High-Performance Computing in Life Science & Education
Sponsored by SGI and Intel
The varied collection of Bio-IT World articles and insights assembled in this BriefingON examine key trends in HPC infrastructure and how researchers are putting their best computational resources to use. Provided here are stories and lessons around the effective use of high performance computing in life science. Download the BriefingON.


Waters white paper image
Software Helps Doping Control Lab Streamline Results Management
Sponsored by Waters
The Karolinska University Hospital’s Doping Control Lab tests thousands of samples annually for stimulants, diuretics, and other masking agents. Increased regulatory pressure and new technologies increased the number of samples analyzed creating data management challenges. Waters® NuGenesis® Scientific Data Management System and TargetLynx™ Application Manager software were used to reduce the time required to calculate, review and search results.


Life Science Webcasts & Podcasts

Medidata Solutions

Rising Clinical Trial Delays and Costs - Addressing the Cause, Not the Symptoms 

medidata podcastProtocol complexity is taking a toll on clinical study speed and efficiency: increasingly complicated and ambitious protocols are not only burdening sites and study volunteers but are also prolonging trials and increasing expenses. In response, sponsors have turned to global study placement, restructured site relationships and new site management practices, but the problem remains.

This podcast will discuss:

  • Why these responses address only the symptoms, not the underlying cause, of rising clinical trial delays and costs.
  • Results of a recent joint Tufts University / Medidata Solutions study.
  • New metrics benchmarking protocol design trends.
  • Systematic protocol design improvements and why they are essential to clinical trial performance excellence.

Speakers: Ken Getz, Senior Research Fellow at the Tufts Center for the Study of Drug Development, and Ed Seguine, General Manager, Trial Planning Solutions at Medidata.

Download Now 



More Podcasts

Job Openings

Director, Center For Information Technology (CIT) - National Institutes of Health  (NIH), Department of Health and Human Service
Located in Bethesda, MD. This position requires:
• High-level vision, leadership, management, and modernization of CIT programs and services.
• Strategic direction and policy development for CIT long-term operations and objectives.
• Serve as a key IT advisor to the NIH Chief Information Officer.
A TOP SECRET security clearance will be required.  More job detail is found at:  http://www.jobs.nih.gov under the Executive Jobs section.Or contact Ms.Winnie Garner at seniorre@od.nih.gov.  Applications must be received ELECTRONICALLY by (11:59 p.m.), December 17, 2008.  DHHS and NIH are Equal Opportunity Employers

Bioinformatics Manager- Lilly Singapore Centre for Drug Discovery
For more information click here 

For reprints and/or copyright permission, please contact The YGS Group, 1808 Colonial Village Lane, Lancaster, PA;

(717) 399-1900 ext. 125, or via email to Ashley.Zander@theYGSgroup.com.