| What Was Simulated |
Simulator |
Detail |
| Treatment of type 2 diabetes with Irbesartan |
Center for Outcomes Research, Basel |
Computer predicted Irbesartan would delay end-stage renal disease by >1 year |
| How stroke affects U.S. population |
Duke University |
Model compares cost-effectiveness of new, existing therapies |
| Anti IL-5 therapies against asthma |
Entelos, Aventis collaboration |
Based on computer predictions, Aventis stopped research early |
| Stimulation of mast cells, sensory nerves in asthma |
Entelos, Merck collaboration |
Computer, real-world clinical trial results concurred, but few additional insights |
| Delivery of a drug into the brain |
GlaxoSmithKline |
Computer helped optimize factors affecting in vivo rate of delivery |
| Effects of migraine medicine Naratriptan (Amerge) on body |
Manchester University, U.K. |
Simulation matched real-world trials, helpful in assessment of uncontrollable factors |
| Treatment regimen for thrombopoietin |
Optimata Ltd., Israel |
Computer accurately predicted platelet counts for individual rhesus monkeys |
| Efficacy of Ziduvudine against HIV/AIDS |
Pharsight for unidentified client |
Model included 3,000, "city" and "suburban" virtual patients with specific genotypes |
| Can drug (mycophenolate mofetil) reduce odds of rejecting kidney transplant? |
Pharsight for unidentified client |
Model helped design of clinical trial in real world |
| 30 separate Phase IV trials |
Pharsight for unidentified client |
Simulation evaluated company research projects, found one high-value strategy |
| Economic, lifestyle effects of breast cancer therapies |
Simul8, ABCSim software |
Simulation predicted how a variety of factors would affect each other |
| ADME effects of antiviral medicine |
ganciclovir Trega Biosciences, Italy |
Simulation discovered reason for low bioavailability: solubility, not permeability |
| Prostate cancer diagnosis, risk assessment |
University Medical Center, Rotterdam |
Helped plan rationale for screening program for prostate cancer |