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Dear Colleague,
Welcome to this week's eNewsletter covering breaking R&D news, business insights, and a feature on pharma's expansion into Singapore. Click "More" to read the full stories.

 
BREAKING R&D NEWS
 

J&T refuses PPF offer for Zentiva shares
Reuters [Jun 23] J&T Financial rejected a PPF offer to buyout pharma company Zentiva after a more generous offer of $2.6 billion came in from French company Sanofi-Aventis. Zentiva management advised shareholders on Friday not to accept the PPF's bid and called an extraordinary shareholder meeting for July 9. The board had no comment on the counter offer from Sanofi-Aventis.More

Stiefel Laboratories buying Barrier Therapeutics
CNN Money [Jun 24] Stiefel Laboratories, a privately-held company focusing on dermatology products, will buy Barrier Therapeutics for about $148 million in a bid to expand Stiefel’s line of oral and topical skincare treatments. The deal has been approved by Barrier’s board of directors but is still subject to a tender offer. More

"Virtual man" may ease drug R&D woes: report
Reuters [Jun 19] New computing technologies and the evolution of a "virtual man" to predict the effects of new drugs before they enter clinical trials could transform the fortunes of pharmaceutical research, a report said on Friday. By 2020, the drug research and development process may be shortened by two thirds, clinical trial costs slashed and productivity increased dramatically, said the report from consultancy PricewaterhouseCoopers (PwC). More

 
 
BUSINESS INSIGHTS 
 

U.S. Probe of Glaxo’s Paxil Widens
Wall Street Journal [Jun 20] A Justice Department investigation of GlaxoSmithKline PLC's handling of its blockbuster antidepressant drug Paxil, including its marketing and safety research, appears to be widening. GSK confirmed Thursday that a previously disclosed Colorado-based Justice Department investigation of marketing practices also includes the Boston U.S. attorney's office and is being coordinated by the agency in Washington. More

Merck cholesterol drug likely delayed until 2013
Boston Globe [Jun 20] Merck said it will probably be 2013 before regulators reconsider approval of the cholesterol drug the company was counting on to rejuvenate sales growth. The Food and Drug Administration rejected the drug in April, saying it needed more information from company studies. After a recent meeting with the FDA, Merck said the agency wants to see final results from a study that won't be completed until January 2013. The study involves 20,000 patients and only 12,000 are currently enrolled. More

Analysts: Sanofi's Zentiva bid may signal strategy
Boston Globe [Jun 18] Sanofi’s bid for Zentiva may seem forced by the earlier PPF offer, but it could also signal a strategic move by the French drug maker into the generics business and the Eastern European market. More

Turning personalized medicine into reality
Sign On San Diego [Jun 18] It's been a hot couple of years for genomics, the study of the long chain of chemicals that determines all the hereditary information in a person's DNA, from hair and eye color to propensity for disease. Only a few years ago, mapping a genome cost millions of dollars and took years to complete. Now the process is faster and costs just thousands of dollars. More

LAST WEEK'S TOP STORY
 

Pancreatic Cancer Biomarkers Found
Washington Post [Jun 13] Five proteins linked to early development of pancreatic cancer have been identified by U.S. researchers, who said the finding is a step forward in efforts to develop a blood test to detect this type of cancer in the early stages, when cure rates are highest. More

For More Recent Articles >>

 

LIFE SCIENCE JOBS

Friedrich Miescher Institute for Biomedical Research - Part of the Novartis Research Foundation
Basel, Switzerland is looking for a Head of IT Systems & Infrastructure. You will manage a cutting-edge core server and network infrastructure, comprising Linux and Solaris, as well as a robust Windows and Macintosh environment. We look forward to receiving your application:
 human.resources@fmi.ch. click for more information

Lilly Singapore Center for Drug Discovery (LSCDD) - Associate Director of Informatics,
Lead and mentor a strong team for the Bioinformatics group at the Integrative Computational Sciences (ICS) department at LSCDD towards the development of novel algorithms, data analysis methods and software tools for drug discovery. Work closely with the Software Engineering group at ICS, and collaborate with the Discovery IT organization in Europe and USA. For additional information, or to apply visit:
 LSCDD

Lilly Singapore Center for Drug Discovery (LSCDD)- Senior Bioinformatics Scientist,
Contribute to the development of novel algorithms, data analysis methods and software tools for drug discovery as part of the Integrative Computational Sciences (ICS) department at LSCDD.  Work closely with informatics and software engineering peers at ICS, and collaborate with the Discovery IT organization in Europe and USA. The successful candidate will offer hands-on insight and expertise in tailored therapeutic informatics and statistical analyses at the post-genomic era. For additional information, or to apply visit:
 LSCDD   

Lilly Singapore Center for Drug Discovery (LSCDD) - Manager, Software Engineering (Integrative Computational Sciences)
Join the Integrative Computational Sciences (ICS) department at Lilly Singapore Centre for Drug Discovery (LSCDD),as Manager Software Engineering.  Lead the development of integrated applications to process and visualize data from cutting edge technologies used by scientists at Lilly Research Labs (LRL) and the Drug Discovery Research (DDR) teams. Masters in Computer Science/Engineering or related discipline, 10+ years post graduation experience , 2 years management experience needed. For a complete job description and requirements or to apply visit:
 LSCDD 

Lilly Singapore Center for Drug Discovery(LSCDD) -Senior Software Engineer,
Join a strong team of software engineers in our Integrative Computational Sciences (ICS) at LSCDD. Collaborate with, and help develop integrated applications to process and visualize data from cutting-edge technologies used by scientists at Lilly Research Labs (LRL) and the Drug Discovery Research (DDR) teams. The Software Engineering team provides computational tools and tailored software solutions that enable the global effort of Tailored Therapeutics; ‘The Right Drug, at The Right Dose for The Right Patient at The Right Time'. For additional information, or to apply visit: LSCDD  

Memorial Sloan-Kettering Cancer Center - Application Analyst
MSKCC Genomics Core seeks an Application Analyst to configure UNIX and Windows systems, maintain LIMS server and install analysis software. Requires a Master’s degree, UNIX experience, and knowledge of a language besides PERL beyond the beginning level. Email Jobops5@mskcc.org or
 www.mskcc.org #015563. EOE/AA

Memorial Sloan-Kettering Cancer Center - Bioinformatics Engineer MSKCC Bioinformatics Core in Manhattan seeks Bioinformatics Engineer. Design and develop bioinformatics
processing and analysis pipelines for traditional and next-gen sequence data. Consult with, train, and analyze data for researchers. Master's degree and 5 years experience in Bioinformatics software development, sequence assembly, SQL, Perl, Python. Email
 bic-jobs@cbio.mskcc.org or www.mskcc.org #015415. EOE/AA

Memorial Sloan-Kettering Cancer Center - Linux Systems Administrator - MSKCC Bioinformatics Core in Manhattan seeks Linux Systems Administrator. Install, configure and update OS, databases, software. Monitor and troubleshoot HPC cluster, email and web servers. Master's degree and 5 years experience with HPC, network security, Postfix, Apache, Tomcat, Grid Engine. Email bic-jobs@cbio.mskcc.org or www.mskcc.org #015429. EOE/AA

Paradigm-Sales/Business Development – IT Solutions and Services
Paradigm (
www.Paradigminfotech.com) is a global IT services and solutions provider. Paradigm has over 1000 employees and is the recipient INC. 500 and D&T Fast 50 consistently.  Paradigm is looking for SALES / BUSINESS DEVELOPMENT PEOPLE.  Experience: 2-3 years Direct sales experience in Software Solutions or Services including Application development or support and preferably selling to Pharmaceutical, CROs or Health care industries. Location:Columbia, MD,Contact:  Erin Lowman, erin@paradigminfotech.com, 410-872-1008 x 100

Unilever - Mathematical Modeller (Research Scientist)
This research is leading to the requirement for integration of both biological and chemical data that may not be amenable to analysis through traditionally used techniques. The ability to work in multidisciplinary teams alongside biologists, chemists and statisticians plus enthusiasm for learning new science is critical for the role.   For a complete job description and to apply, please visit:
 https://unilever.recruitmax.com/ 

More Life Science Jobs ~ Add a Job Listing

 

FEATURED EVENTS

Computing Short Courses at MIT - June / July - Cambridge, MA 

2nd Label-Free Protein Array- Latest Advances in Analysis of Macromolecular Interactions,July 3-4th 2008 -Paris- France
 

Barnett Educational Services, 2008 Schedule

To have your event featured here, contact Lynn Cloonan for more information.

 Email to a Friend 

FEATURED CONTENT 

Building Buzz in Singapore 
By Allison Proffitt

June 10, 2008 | SINGAPORE - In Singapore, the food is fantastic, the weather is warm, and the news is always good for scientific investment. At least that's the general impression. It can seem a little too good to be true, and you have to wonder about a massive public relations machine churning out glossy brochures and happy scientists in some back room.

But the country has built its buzz on a solid foundation. Like the three rules of real estate-location, location, location-Singapore sells its proximity to India, China, and the rest of Asia while boasting an English-speaking business environment and a very well-established infrastructure.

Read More

EXCLUSIVE WEBCAST

NEW! Life Science Webcasts from Bio-IT World and Cambridge Healthtech Media Group

Life Science Webcasts

Bio-IT World Expo
Video Highlights

Personalized Genetics: Advancements and Driving Change
Linda Avey, co-founder of 23andMe, delivers her keynote at the 2008 Bio-IT World Conference & Expo in Boston, April 30, 2008.
View the Webcast Now.

The Future of Personal Genomics
A distinguished panel of personal genomics experts discuss the future of personal genomics at the 2008 Bio-IT World Conference & Expo in Boston, April 30, 2008.  They include Dietrich Stephan (co-founder, Navigenics); George Church (Harvard Medical School);
Jeff Drazen (editor-in-chief, New England Journal Medicine); Fred Ledley (Bentley College); John Halamka (CIO, Harvard Medical School); and Linda Avey (23andMe). Bio-IT World Editor-in-Chief Kevin Davies moderates the discussion.
View the Webcast Now

Insight Pharma Reports

Systems Biology: A Disruptive Technology
This report focuses on current and future applications of Systems Biology in drug discovery and describes radically new concepts emerging from basic Systems Biology research. More Information

Custom Market Research Services
Our experienced research team will work with you to fully understand your needs in order to create and conduct a custom market research program that meets your objectives.
Learn More

Featured Content

Will Healthcare IT Trends Standardize?
A new wave of activities are driving transformation within the healthcare market. One solution is found in a guide to PDF Healthcare Best Practices. This “Best Practices Guide” describes Portable Document Format (PDF) attributes and use to facilitate the capture, exchange, preservation and protection of healthcare information. This webinar will focus on trends in today’s healthcare market, the challenges in overcoming these issues, and finally how to use best practices to improve patient care, enhance productivity and eliminate paperwork. It’s hosted by Adobe and moderated by Digital Healthcare & Productivity Executive Editor, John Russell. Click here...
 

To have your white paper featured here, contact Lynn Cloonan for more information.

 

Spain’s Emerging Biotech Revolution
The biotechnology sector is growing 10 percent faster in Spain than it is in the U.S. Driven by a culture, government and private sector that are open-minded and optimistic, Spain-based companies are emerging as leaders in this dynamic field. Discover how your business can capitalize on creative solutions from Spain-based enterprises. Download Now

Waters
Automate Method SOPs for Greater Efficiency and Fewer Errors with Waters® NuGenesis® Intelligent Procedure Manager
The Waters® NuGenesis® SDMS Intelligent Procedure Manager is a workflow software package designed to guide the laboratory analyst through a routine, comprehensive method standard operating procedure (SOP) and integrate results with a chromatography data system. The Intelligent Procedure Manager addresses the predominately manual activities required to perform an analytical method or test, reducing cycle times up to 50-75% as compared to a traditional paper trail with fewer opportunities for human error.  From late-stage development to final product quality control and lot release, Intelligent Procedure Manager can be applied to any lab environment where rigorous adherence to approved test methods and SOPs must be followed, including compliance requirements for cGMP operations.Download Now
 
 
  
  

This Bio•IT World Briefing On “Next-Generation Sequencing,”underwritten by GenomeQuest, Inc.,
presents a selection of feature stories, interviews,commentaries, conference reports, and editorials on the emergence, opportunities, and challenges posed by high-throughput sequencing. Covered in this collection: the launch of new platforms from Applied Biosystems and Helicos; new applications of nextgen sequencing; the rise of personal genomics; and informatics solutions to vexing problem of managing the vast volumes of next-gen data. Download now 


SGI's Meeting Today’s Computational Needs for Science
The quest to better understand disease mechanisms and find new treatments is driven by new laboratory technologies and ever-more sophisticated modeling and simulation efforts. As such, life sciences R&D investigations increasingly are relying on more powerful computing resources. The challenge is how to accommodate the broad mix of applications.
Addressing this issue, this paper produced by the Bio-IT World Custom Publishing Group discusses a new SGI Hybrid Computing Environment approach. It optimally uses shared memory systems, multi-processor clusters, and FPGAs to accelerate computational workflows. Download This Free Paper 


Cambridge
                                Healthtech InstitutePublished by Cambridge Healthtech Institute (CHI). Copyright © 2008, all rights reserved. No material may be reproduced electronically or in print without written permission from CHI, 250 First Ave., Needham, MA 02494-2814. For reprints and/or copyright permission, please contact The YGS Group, 1808 Colonial Village Lane, Lancaster, PA; 17601 717-399-1900 ext.110, or email: becky.mullaney@theYGSgroup.com