Cover Story
Integrating Clinical and Genomic Data
With assists from Oracle and InforSense, Dana-Farber’s John Quackenbush finds ways to mine vast patient data collections to better understand human cancer.

Up Front
"Breathtaking” Biology Shimmers on Marco Island 
At AGBT, new technology heralds exciting new biology.

Merck Execs See ‘Sage’ as Key Ingredient for Disease Biology
Merck execs tout new venture as key ingredient for disease biology. 

Are Patent Offices Ready for Personalized Medicine? 
New science presents unique challenges to the patent system.

Inside the Box | The State of Kits 
We may be ready for an open source, next generation toolkit.

Insights Outlook | Expanding Molecular Diagnostics 
Molecular diagnostics has exciting opportunities.

News Briefs

Computational Biology
Keeping Science Connected the Web 2.0 Way
The rise of scientific social networking is paying dividends for users and entrepreneurs alike.

Computational Development
Chasing Cellular Systems Biology
Cellumen uses high content screening to flag tox-causing compounds.

Agile IT Strategy in Pharmaceutical R&D
Clearly communicated aims should be the goal.

Ted Slater’s Semantic Technologies
The semantic web doesn’t exist, but Pfizer’s Slater believes semantic technologies are paving the way.

Platforms for Personalized Medicine
Integrating clinical information and R&D data will ensure success.

Clinical Research
A Web MD: Paul Bleicher Reflects on Phase Forward 
Bleicher talks about Phase Forward’s acquisitions, milestones, and what’s next.

MacGarvey Establishes Quanticate’s U.S. Operation
The Cambridge office expands reach of clinical trial services and products in North America.

In Every Issue
First Base | Real Time Research and the Long Tail of Disease
Jay Tenenbaum urges pharma to share resources. 

The Russell Transcript | CoSBI Models 
Corrado Priami, president of CoSBI hopes to infer principles from living systems to improve computer science. 

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