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Harvard’s Pardis Sabeti describes her team’s exciting progress in mapping signals of positive selection in the genome (see “Testing Positive,” Bio•IT World, March 2010). These genes (and probably non-coding RNAs), have been selected during recent human history and population migration, shaping everything from resistance to infectious disease to thermoregulation, body mass index to characteristics of hair and teeth. As one member of the audience remarked, Sabeti is “rewriting the textbook of evolution.” Equally exciting is what Sabeti hopes to find now she is integrating sequence data from the 1000 Genomes Project.


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