September 2, 2010
| Bio-IT World

Industry Trends
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The “Net Innovation Trend” and What It Means for Big Pharmas, Biotechs, and Generics

By Mark P. Mathieu
Innovation is the key value driver in healthcare.  Over the past 8 years, the pharmaceuticals sector has lost a stunning $593 billion (-65%) in market cap while the two sectors with innovation – biotech and med tech – have each added $71 billion (+46%) and $19 billion (+6%) in market cap, respectively.  Read More


Top Headlines


Isilon Rolls Out Unified Scale-Out Storage Platform
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Bio-IT World | Data storage company Isilon is introducing what it claims is the industry’s first and only unified scale-out storage platform for the enterprise, by integrating the iSCSI protocol into its OneFS operating system.

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Sanofi Calls Genzyme to the Table
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Forbes | Yesterday Sanofi-Aventis sent a formal "bear hug" letter to Genzyme shareholders hoping to start real negotiations. The letter didn't raise the offer of $69/share, but instead called Genzyme to the negotiation table or Sanofi would "consider all alternatives".

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Genetic Red Flag for ALS
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HHMI | Researchers at Howard Hughes Medical Institute (HHMI) have found a genetic risk factor for amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease).

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Introducing the Next Next Gen
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Australian Life Scientist | The third generation of sequence technology does away with cloning and PCR, and instead relies of fluorescense, single molecule sequencing, or silicon chips. Fueled by semi-conductor technology and electrical current, it will likely be Ion Torrent or Oxford Nanopore that reaches the goal of the $1000 genome first.

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Share the Data: Making Large-Scale Proteomics Data Widely Available
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Bio-IT World | Expert Commentary | Advancements in science and health care are made possible through widespread access to cutting-edge research data, as was clearly demonstrated during the Human Genome Project, where researchers collaborated to create an extensive data resource for the entire community. The proteomics community is beginning to implement analogous policies and infrastructure.

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Hugh Rienhoff Cops a Candidate Gene in His Daughter’s DNA
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Bio-IT World EXCLUSIVE | Hugh Rienhoff’s relentless search for the genetic basis for his daughter’s mysterious congenital syndrome has finally unearthed a legitimate but still unproven candidate for the disorder -- a homozygous frameshift mutation in the gene for copine-1.

 

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White Papers & Special Reports

oracle_RDC
Remote Data Capture:Acquisition and Analysis
Sponsored by Oracle

See why Electronic Data Capture (EDC) is gaining traction in the pharmaceutical
clinical trials arena. Today approximately half of all clinical trials are conducted
electronically, and the figure is rapidly rising. Report includes contributions from
Oracle Health Sciences, Pfizer, PPD, and C3i.

 

oracle20723
The Role of Analytics in Transforming Healthcare
Sponsored by Oracle

Sharing many of the data challenges and opportunities faced by Healthcare, the Life Sciences industry remains focused on delivering new, innovative therapies and solutions to patients in a cost effective, timely and safe way. With spiraling R&D costs, new methods such as adaptive trials, and never ending need for deep pharmacovigilance, the Life Sciences companies that effectively use analytics to explore, monitor and optimize their business will rapidly become the new leaders.

Oracle’s strategy—built upon Enterprise Health Analytics and Health Data Warehouse Foundation—provides a powerful, practical, and extensible approach to delivering the IT analytics infrastructure required to confront the worldwide healthcare challenge.

pegasystems
BPM-Based Case Management Approach to Optimizing Clinical Trial Efficiency
Sponsored by Pegasystems

Business Process Management (BPM) software offers liberation in the planning and management of clinical trials today. SmartBPM provides the components for automating critical clinical trial processes ranging from protocol development and patient enrollment to site management and investigator payments. Advantages are:

  • Potentially stunning return on investment at multiple levels.
  • A 500%, or better, increase in application development time by directly executing business requirements
  • Improved customer retention
  • A 50% possible reduction in training time

Discovered is opportunity to enhance relationships with investigators, subjects, and regulators while bringing momentum to a technology-impaired study startup phase. Learn more about SmartBPM in this complimentary white paper.



Expert Comment

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Making sense of R&D data in a networked life science model

By Ben McGraw

August 16, 2010 | When researchers at the Cancer Vaccine Center (CVC) at Dana-Farber Cancer Institute (DFCI) began to study the cancer vaccine field, they gathered data from more than 645 vaccine trials, including cancer types, incidence, and survival rates, in order to identify relationships, trends and patterns. Read more.  

Bio-IT World invites contributed Expert Commentaries. Contact Kevin Davies with proposals.

Life Science Webcasts & Podcasts

Bio-IT World & CHI

Impact of the 1000 Genomes Project on the Next Wave of Pharmacogenomic Discovery
1000genomeInterview with M. Eileen Dolan, Ph.D., Professor, Medicine, University of Chicago and Speaker at Next-Generation Sequencing Data Management, September 27-29, 2010, Providence, RI  

The 1000 Genomes Project aims to provide detailed genetic variation data on >1000 genomes from worldwide populations using the next-generation sequencing technologies. Some of the samples utilized for the 1000 Genomes Project are the International Hap-Map samples that are composed of lymphoblastoid cell lines (LCLs) derived from individuals of different world populations. The detailed map of human genetic variation promised by the 1000 Genomes project will allow a more in-depth analysis of the contribution of genetic variation to drug response. Future studies utilizing this new resource can greatly enhance our understanding of the genetic basis of drug response and other complex traits.


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Software Engineer – Computational Biology Center

Memorial Sloan-Kettering Cancer Center seeks an Engineer to design and develop complex data analysis systems in support of cancer genomics research projects at the Computational Biology Center. Qualified candidate will have a BA, 5+ years of software development experience and expert knowledge of Java, SQL, and HTML.

Apply: www.mskcciscareers.org.  Equal opportunity and affirmative action employer.

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