January 28, 2012
| Bio-IT World
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Industry Trends

Next Generation Sequencing Generates Momentum: Markets Respond to Technology and Innovation Advances - Overview

Author: Ken Rubenstein, PhD

This report focuses on current and innovative NGS technologies, services and markets to answer such questions as:

  • Which early NGS market entrants have been continually improving and updating their original systems?
  • Who has introduced new scaled-down instruments to broaden the market?
  • What Generation 2.5 systems featuring new detection technologies and single-molecule sequencing are now on the market?
  • When will third generation of instruments led by nanopore technologies be entering the commercial feasibility stage?
  • Why upstream sample handling is undergoing continual technological innovation?
  • Which informatics providers are moving rapidly toward fully integrated systems to provide the rapid generation of actionable biological information?

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Bio-IT World Best Practices Award: Submit your entry today … Deadline is February 15th!
This prestigious awards program is designed to recognize outstanding examples of technology and strategic innovation—initiatives and collaborations that manifestly improve some facet of the R&D/drug development/clinical trial process.
Click here to learn more.  

Top Headlines


Branding Academic Publishers 'Enemies of Science' is Offensive
| The Guardian | Noting that scientific publishers "are not philanthropists, charities or funding agencies," a member of the industry pens a rebuttal to recent staunch criticism that academic publishers are "anti-science" and "anti-publication" in light of the proposed US Research Works Act. more
Accelrys' Cheminformatics Solution in HEOS Cloud
| Bio-IT World | The Accelrys next-generation informatics suite consists of updated existing products and components, but perhaps most noteworthy is the marriage with a cloud-based product called HEOS, in partnership with Scynexis, for externalizing research.  more
UK Scientists Call For National DNA Database for Personalized Medicine
| Daily Telegraph | In a report to the UK government, a group of UK scientists argues that a national DNA database is needed if the National Health Service is to capitalise on advances in technology and offer personalised genomic medicine to all in the future. more
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Roche Launches Hostile Bid for Illumina to Reclaim Next-Gen Sequencing Mantle
| New York Times | Roche, the Swiss drug maker, has launched a $5.7 billion hostile bid for Illumina, going directly to the company’s shareholders. In early trading, Illumina shares soared some 40%, trading above the $44.50 Roche was willing to offer. more
Good Days and Bad in 2011
| Bio-IT World | Physicists seem to be having all the fun right now -- monster black holes, inhabitable planets, glimpses of God particles and hearty challenges to Einstein. But a list of last year's top ten science stories in the Guardian found room for only a couple of items in contemporary biology.  more
Children’s Hospital Launches CLARITY Challenge for Clinical Genome Interpretation
| Bio-IT World | Researchers at Children’s Hospital in Boston have launched the $25,000 CLARITY Challenge, to develop standards and best practices for clinical genomic analysis and interpretation. Project co-founder Isaac Kohane says an open contest is the best way to catalyze "a public and transparent improvement of that pipeline."  more






White Papers & Special Reports

hp_risk_mng
Technology Strategy Guide to Business Risk Management for Healthcare
Sponsored by HP

Disaster Recovery best practices, combined with selective technology solutions and improved systems management, can reduce business risk for healthcare organizations.  

This complementary strategy guide explores way to: 

  • Reduce the labor of preparing for, and recovering from, a disaster   
  • Save up to  90% reduction in IT staff time spent backing up the environment 
  • Reduce by up to 87% the amount of time spent recovering from an outage. 

   

hp b2b ehr
Successful EHR Change Management
Sponsored by HP

This informative paper monitors where your staff may be in terms of resistance or support for a new Electronic Health Records (EHR) system. It walks you through processes for assuring they have proper tools, training and support to accomplish successful EHR implementation, which includes: 

  • Assessing baseline skills and abilities 
  • Analyzing existing workflows 
  • Defining roles and expectations, and designing training. 
  • Building the transition team, and setting the EHR goals. 

Doing this right places you, as an IT professional , at the center of efforts driving an effective transition process.  

 

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A BPM-Approach to Adverse Event Management
Sponsored by Pegasystems

Safety management is one of the most difficult requirements imposed on the life sciences industry. Companies confront a tangle of safety monitoring requirements that span both pre- and post-market approval activities and vary by IRB/IEC governance policies, product type, and different global regulatory agencies. Learn how Pegasystems BPM and its Adverse Event Case Processing Solution (AECP) can help companies

  • Transform adverse event management systems
  • Lower cost with increased productivity
     

One client successfully utilized Pega BPM to establish paperless adverse event reporting across 23 countries, resulting in upwards of a 100% increase in productivity with near 50% cost reduction.
 




Expert Comment

What Should We Call 'Systems Biology'?

By Desmond Smith

Systems biology lies at the very heart of modern biomedical research and a number of review articles and conferences have caught the spirit of this movement. The discipline encompasses an assortment of related but distinct concepts, including the idea that detailed and comprehensive data from living systems will enable robust prediction of their trajectory and also the paradoxical notion that some biological behaviors occur in a relatively surprising and unexpected fashion, so-called emergent properties.

However, the ideas underlying systems biology are not new. First articulated by a number of researchers in the 1960s, some of the principal notions were also articulated by Francis Crick in a visionary Nature review article in 1970 that anticipated the state of molecular biology in the year 2000. In his article (Nature 228, 613-615 (Nov 1970)), Crick stated that “problems involving complex interactions can hardly be avoided… a simple example would be the ‘total’ behavior of a microorganism such as Escherichia coli, including all of its regulatory mechanisms.” Read more. Bio-IT World invites contributed Expert Commentaries. Contact Kevin Davies with proposals.  

Life Science Webcasts & Podcasts

medidata podcast #8 Meeting Today’s Challenges in Clinical Trial Supply Management
Sponsored by: Medidata Solutions Worldwide  

Setting up and managing the clinical trial involves many complex procedures. Among the most challenging are planning and executing the logistics of the trial’s clinical supplies. This podcast focuses in depth on the following topics which trace current practices and future evolution of this crucial aspect of clinical trials:

  • Current practices in clinical trial logistics
  • Comparing advances in clinical supply practices to  other aspects of clinical trials 
  • Where current practices fall short of meeting the challenges
  • Trends and evolving improvements that may change the way logistics are conducted

Listen Now  




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Job Openings

tessella logo 
Scientific Software Engineer
Boston MA
$70,000 to $95,000
 

Tessella delivers software engineering and consulting services to leading pharmaceutical and biotech companies. We are recruiting Software Engineersto work with skilled bioinformaticians and scientists to identify business needs and recommend and develop technical solutions. Applicants require BS, MS or PhD in bioinformatics, biology or chemistry and 2+ years of software development in either: Java, C#, C++, C or VB.NET. 

Apply at http://jobs.tessella.com   

 

oxford nanopore logo 


 Early Access Collaborations Managers
Oxford Nanopore Technologies is developing a novel technology, GridIONTM for the direct, electronic analysis of DNA/RNA and other analytes.  As the system approaches the market, we are building a team of technically knowledgeable, highly motivated candidates with excellent customer service and facilitation skills to join our company as Collaboration Managers.  This is a unique opportunity to work with world-leading genomics customers throughout the early adoption phase of a new generation of DNA sequencing technology.. This is a facilitative, enabling role with responsibility for managing technology development collaborations with key customers at leading genomics institutions.  It will include long term management of the collaboration plan and milestones and associated meetings and documentation. Click here to find out more and apply   

Oxford Nanopore's GridION technology, VP, Sales and Marketing Oxford Nanopore Technologies is a fast-moving technology company that is developing a novel electronic molecular analysis technology. The technology is adaptable for the analysis of DNA/RNA, proteins, chemicals and other molecules.  It is therefore suitable for use in a variety of markets including scientific research and clinical applications.  As the technology approaches the market, Oxford Nanopore is seeking a visionary VP of sales and marketing to join the senior team.  The candidate will embrace the opportunities afforded by entering the market with a truly disruptive technology that has the potential to expand the number of users and the variety of applications in each target market.  This is a rare opportunity to influence the commercial strategy at an early phase of its commercial lifetime, in a well funded company.  Oxford Nanopore welcomes applications from candidates with a track record of high-level strategic commercial  leadership, who wish to apply a fresh approach to existing markets.  Experience in Life Sciences/DNA sequencing is central to this role, however we will consider your application if you have experience of disruptive technologies in other related industries.  We are particularly interested in candidates with strong expertise in the use of digital technologies for sales and marketing of scientific/technical products.  Click to  Apply  


 

For reprints and/or copyright permission, please contact  Tim McLucas, (781) 972-1342, tmclucas@healthtech.com .