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In a Restless Preclinical Testing Market, Organs-on-Chips Company MIMETAS Is in Expansion Mode

| Bio-IT World | Dutch startup MIMETAS, whose microfluidics technology forms a platform for three-dimensional, multi-cell-type tissue cultures, is securing new funding and partnerships as it expands its line of drug screening models.

Expanding the Search for Knockout Mutations to the Human Population

| Nature News | With mass sequencing of humans now a practical reality, several large population studies are searching for people with rare mutations that completely knock out specific genes, to uncover these genes' functions and potentially new drug targets.

Large Funding Round for Massachusetts Biotech Syros

| Xconomy | Syros Pharmaceuticals, a biotech focused on creating drugs that target gene expression regulatory pathways, has announced a $53 million Series B financing round.

The Peculiar Internet Market for Genetic Health Reports

| MIT Technology Review | Since the FDA made clear last November that it would not tolerate companies selling genetic tests linked to health reports without regulatory approval, a workaround for customers of companies like 23andMe has emerged online.

New Microscopy Technique Offers Astounding Resolution Over Time

| Bio-IT World News Brief | A paper published today in Science describes a new type of fluorescence microscope that is capable of taking images of living, three-dimensional systems over long periods of time without degrading cells or fluorescent molecules.

Inside the HIVE, the FDA's Multi-Omics Compute Architecture

| Bio-IT World | At the FDA's Center for Biologics Evaluation and Research, a custom distributed computing system called HIVE takes a new approach to storing and analyzing huge sets of genomic and other biological data.

New Data and Deployments from Edico Genome

| Bio-IT World News Brief | Edico Genome, a San Diego-based company manufacturing application-specific integrated circuits for processing genomic data, this week announced the broad commercial launch of its flagship DRAGEN processor.

Instant Genome Browsing Over the Web with the NextCODE Exchange

| Bio-IT World | NextCODE Health has launched a new genomic data sharing environment, in which collaborators can browse and analyze one another's whole genome datasets at single-base resolution, as well as make individual variants publicly visible for research on rare genetic disease.

BLAST in the Amazon Cloud

| Bio-IT World News Brief | The National Center for Biotechnology Information (NCBI) has declared that its installation of BLAST in the Amazon Web Services Marketplace is "the easiest way to start an NCBI BLAST instance."

PacBio Releases New Chemistry

| Bio-IT World News Brief | Pacific Biosciences, maker of the RSII sequencing instrument, has launched a new reagent kit to boost both the throughput and read length of its sequencers.

2015 Bio-IT World Best Practices Call for Entries Is Open

| Bio-IT World | Bio-IT World is now seeking entries for the 2015 Bio-IT World Best Practices competition, an awards program that for eleven years has highlighted technology innovations to enable drug discovery, biomedical research, and the practice of medicine.

The Next Generation of DNA Vaccines Is Poised to Transform the Healthcare Landscape

| Bio-IT World | Contributed Commentary | Teri Heiland argues that advances in vaccine delivery and vector design are paving the way to safe and effective nucleic acid vaccines, which could be used against pathogens, allergies, autoimmune disease and in the growing field of cancer immunotherapy.

Cell Culture Model of Alzheimer's First to Recapitulate Key Physiology

| Bio-IT World News Brief | A new model of Alzheimer's disease, created at the Genetics and Aging Research Unit of Massachusetts General Hospital, is the first to recreate both the "plaques" and the "tangles" that the amyloid hypothesis predicts are central to the disease's symptoms.

Copy Number Variants in Neurological Disease

| Pacific Standard | More reliable methods for detecting large copy number variants across the whole genome are helping to reveal the importance of these mutations in explaining neurological disorders.

Roche Purchases AbVitro's DNA Enrichment Technology for Clinical Samples

| Bio-IT World News Brief | Roche, which has been retooling its next generation sequencing strategy since beginning the closure of 454 Life Sciences last October, has acquired a new sample preparation technology for an NGS pipeline.

Illumina Opens BaseSpace to Proteomics Data

| Bio-IT World | The OneOmics Project, a partnership between Illumina and mass spectrometry provider AB SCIEX, has produced a network of apps in the BaseSpace cloud informatics environment to store and analyze mass spec and proteomics data, the first multi-omics functions in Illumina's flagship analytics project.

BRCA2 Protein Structure Described

| Imperial College London News | The BRCA1 and BRCA2 genes are well known for mutations that raise the risk of developing breast cancer, but their structure, and the mechanisms by which healthy copies of these proteins repair broken DNA strands, have been little understood.

Nobel Prize Awarded for Decoding Geometrical Pattern of Brain's Spatial Awareness

| Nature News | Norwegian neuroscientists May-Britt and Edvard Moser today received the 2014 Nobel Prize in Physiology or Medicine, along with former supervisor John O'Keefe, for their discovery of "grid cells" in the brain's entorhinal cortex.

FDA Issues Draft Guidance on Laboratory Developed Tests

| Bio-IT World News Brief | Today, the FDA officially issued a pair of draft guidance documents outlining its regulatory plans for laboratory developed tests.

September News and Product Briefs

| Bio-IT World | News and product releases from around the industry, including early-stage pharma startups supported by GSK and Avalon Ventures, and the Eaglecore cloud knowledge management platform.
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