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Inside the HIVE, the FDA's Multi-Omics Compute Architecture

| Bio-IT World | At the FDA's Center for Biologics Evaluation and Research, a custom distributed computing system called HIVE takes a new approach to storing and analyzing huge sets of genomic and other biological data.

New Data and Deployments from Edico Genome

| Bio-IT World News Brief | Edico Genome, a San Diego-based company manufacturing application-specific integrated circuits for processing genomic data, this week announced the broad commercial launch of its flagship DRAGEN processor.

Instant Genome Browsing Over the Web with the NextCODE Exchange

| Bio-IT World | NextCODE Health has launched a new genomic data sharing environment, in which collaborators can browse and analyze one another's whole genome datasets at single-base resolution, as well as make individual variants publicly visible for research on rare genetic disease.

BLAST in the Amazon Cloud

| Bio-IT World News Brief | The National Center for Biotechnology Information (NCBI) has declared that its installation of BLAST in the Amazon Web Services Marketplace is "the easiest way to start an NCBI BLAST instance."

PacBio Releases New Chemistry

| Bio-IT World News Brief | Pacific Biosciences, maker of the RSII sequencing instrument, has launched a new reagent kit to boost both the throughput and read length of its sequencers.

2015 Bio-IT World Best Practices Call for Entries Is Open

| Bio-IT World | Bio-IT World is now seeking entries for the 2015 Bio-IT World Best Practices competition, an awards program that for eleven years has highlighted technology innovations to enable drug discovery, biomedical research, and the practice of medicine.

The Next Generation of DNA Vaccines Is Poised to Transform the Healthcare Landscape

| Bio-IT World | Contributed Commentary | Teri Heiland argues that advances in vaccine delivery and vector design are paving the way to safe and effective nucleic acid vaccines, which could be used against pathogens, allergies, autoimmune disease and in the growing field of cancer immunotherapy.

Cell Culture Model of Alzheimer's First to Recapitulate Key Physiology

| Bio-IT World News Brief | A new model of Alzheimer's disease, created at the Genetics and Aging Research Unit of Massachusetts General Hospital, is the first to recreate both the "plaques" and the "tangles" that the amyloid hypothesis predicts are central to the disease's symptoms.

Copy Number Variants in Neurological Disease

| Pacific Standard | More reliable methods for detecting large copy number variants across the whole genome are helping to reveal the importance of these mutations in explaining neurological disorders.

Roche Purchases AbVitro's DNA Enrichment Technology for Clinical Samples

| Bio-IT World News Brief | Roche, which has been retooling its next generation sequencing strategy since beginning the closure of 454 Life Sciences last October, has acquired a new sample preparation technology for an NGS pipeline.

Illumina Opens BaseSpace to Proteomics Data

| Bio-IT World | The OneOmics Project, a partnership between Illumina and mass spectrometry provider AB SCIEX, has produced a network of apps in the BaseSpace cloud informatics environment to store and analyze mass spec and proteomics data, the first multi-omics functions in Illumina's flagship analytics project.

BRCA2 Protein Structure Described

| Imperial College London News | The BRCA1 and BRCA2 genes are well known for mutations that raise the risk of developing breast cancer, but their structure, and the mechanisms by which healthy copies of these proteins repair broken DNA strands, have been little understood.

Nobel Prize Awarded for Decoding Geometrical Pattern of Brain's Spatial Awareness

| Nature News | Norwegian neuroscientists May-Britt and Edvard Moser today received the 2014 Nobel Prize in Physiology or Medicine, along with former supervisor John O'Keefe, for their discovery of "grid cells" in the brain's entorhinal cortex.

FDA Issues Draft Guidance on Laboratory Developed Tests

| Bio-IT World News Brief | Today, the FDA officially issued a pair of draft guidance documents outlining its regulatory plans for laboratory developed tests.

September News and Product Briefs

| Bio-IT World | News and product releases from around the industry, including early-stage pharma startups supported by GSK and Avalon Ventures, and the Eaglecore cloud knowledge management platform.

TranSMART Platform Powers International Asthma Research Initiative

| Bio-IT World | The U-BIOPRED Consortium, an international project searching for novel biomarkers to better define severe asthma cases, received a Bio-IT World Best Practices Award this spring for its far-reaching implementation of the tranSMART knowledge management platform.

First NIH Grant Awards in BRAIN Initiative

| Bio-IT World News Brief | This morning, the NIH announced the recipients of its first round of grants tied to the nationwide BRAIN Initiative, totaling $46 million in funding for research meant to develop an integrated understanding of human brain function.

New, Larger Facility for Transcriptic Robotics Lab

| Bio-IT World News Brief | Transcriptic, the programmable lab-for-hire, has moved to a new, 10,000-square foot location as it adds more instruments and "work cells" where experiments are conducted.

CRISPR Knockin Mice Enable Rapid Gene Editing

| Bio-IT World News Brief | Researchers at the Broad Institute of MIT and Harvard have created a line of mice whose cells naturally express the Cas9 protein used in CRISPR gene editing, which can be used for virtually any gene knockdown experiment.

GeneHub Pulls Its Kickstarter Project to Sequence Whole Genomes for the Masses

| Bio-IT World News Brief | Just two days after launching a Kickstarter campaign to start the world's first brokerage service for personal whole genome sequencing, GeneHub has pulled the plug.
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