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Holiday Reading for a CRISPR Autumn Day

| Bio-IT World | This year has seen the rapid rise of CRISPR gene editing, for which the biotech industry has every reason to be thankful. Intellia Therapeutics, based in Cambridge, Mass., is the third CRISPR company to spring up in the last twelve months, joining Editas Medicine also in Cambridge, and CRISPR Therapeutics, which operates out of Basel and London. Here is a selection of our coverage on this remarkably adaptable gene engineering system.

Misidentified Cell Line List from NCBI

| NCBI News | NCBI's BioSample database now includes a curated list of over 400 known misidentified and contaminated cell lines.

Searching for Common Ground in Autism Genetics

| Wired | Researchers including Evan Eichler and David Ledbetter are looking at groups of people with autism and searching for common underlying genetics.

American Biotech Start-Ups Head To China For Capital Partners

| Forbes | Several US biotechs are finding their funding needs met by venture firms from China.

OK Go to Issue Album on DNA

| The New Yorker | Alt-rock band OK Go, a Grammy-winning group best known for its elaborate Youtube music videos, is enlisting the help of UCLA synthetic biologist Sri Kosuri to encode its latest album, "Hungry Ghosts," on a DNA molecule.

NCBI Breaks Its Annotation Record

| NCBI | NCBI's Eukaryotic Genome Annotation Pipeline has completed the annotation of more than 100 organisms so far in 2014. 81 of the annotations thus far have been first annotations.

BioNano Closes Big Funding Round on Back of Key Irys Sales

| Bio-IT World News Brief | BioNano Genomics, a company headquartered in San Diego whose Irys instrument maps large structural variation in DNA samples, has announced a $53 million Series C financing round, to be invested in international expansion.

Coming by 2023 an exascale supercomputer in the U.S.

| Computerworld | The U.S. has set 2023 as the target date for producing the next great leap in supercomputing, if its plans aren't thwarted by two presidential and four Congressional elections between now and then.

Shire to Move US HQ and 500 Jobs to Greater Boston

| Pharmalot | Shire is shifting U.S. headquarters, 500 jobs and some of its most important operations from suburban Philadelphia to the greater Boston area.

Illumina and bioMérieux to Pinpoint Pathogens with Next Gen Sequencing

| Bio-IT World News Brief | BioMérieux, a French-headquartered biotech specializing in diagnostics and microbe detection, has announced a partnership with sequencing giant Illumina to create next generation sequencing tests for tracking pathogens during local outbreaks.

Splash of Cold Water for Clinical Genomics at Cold Spring Harbor Personal Genomes Meeting

| Bio-IT World | At last week's Personal Genomes meeting at Cold Spring Harbor Laboratory, a debate over the evidence bar for using genetic tests threw into relief some of the stubborn questions around personal genomes' clinical utility.

How Much Does it Cost to Develop a Drug

| Pharmalot | Later today, the Tufts Center for the Study of Drug Development will release a report that will take yet another stab at determining the true cost of developing a medicine. In the meantime, Ed Silverman is running a poll.

Top500 Supercomputer Listing With Minimal Changes

| Computerworld | The latest Top500 list is out, but only one new system made it into the top ten. The Chinese Tiahne-2 has kept its number on position for the fourth time, even though it has not changed its computing power.

Vytorin, LDL-Targeting Drugs Work

| Bio-IT World Roundup | The results of the IMPROVE-IT trial were announced today, a seven-year study looking at whether Merck's Vytorin and Zetia pills actually prevent heart attack. The answer: yes. At least some.

National Labs Buying Next-Gen IBM Supercomputer

| Nature | Oak Ridge National Laboratory (ORNL) in Tennessee and the Lawrence Livermore National Laboratory in California announced today their plans to upgrade to a next-generation IBM supercomputer that will run at 150 petaflops.

Google Increases Award in 'Nobel' Prize of Computing

| Mashable | Google has raised the stakes in the A.M. Turing Award, offering $1 million. The annual awards recognize "major contributions of lasting importance to computing," and until now have included a cash prize of $250,000.

IBM Invests in Pathway Genomics' Watson-Powered Health App

| Bio-IT World | Pathway Genomics yesterday announced an investment from IBM to launch Pathway Panorama, a health-focused mobile app powered by IBM’s Watson’s natural language processing technology and fed by data from Pathway Genomics’ genetic tests.

Inactivated Protein Lowers Risk of Coronary Heart Disease by 53%

| Bio-IT World | A sequencing study published tomorrow in the New England Journal of Medicine has further characterized the activity of the Niemann-Pick C1-like 1 protein (NPC1L1). Carriers of inactivating mutations of NPC1L1 were found to have a 53% lower risk of coronary heart disease and an average LDL cholesterol level 12 mg per deciliter lower than that of noncarriers.

De Novo Human Genome Assembly Using Long Reads

| Bio-IT World News Brief | Evan Eichler of the University of Washington and colleagues have published a paper in Nature detailing a new whole human genome assembly, using the long-reading SMRT sequencing technology of Pacific Biosciences.

Breakthrough Prizes Highlight CRISPR Gene Editing, Gene Regulation

| Bio-IT World | Emmanuelle Charpentier and Jennifer Doudna, co-discoverers of the CRISPR-Cas9 mechanism that has swiftly become a groundbreaking tool in genetic engineering, are among this year's winners of the $3 million Breakthrough Prizes in the Life Sciences awarded by a coalition of tech billionaires.
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