Weill Cornell Medicine and the New York Genome Center Awarded NCI Grant to Create Genomic Data Center
By Bio-IT World Staff
November 3, 2016 | Weill Cornell Medicine (WCM) and the New York Genome Center (NYGC) were recently awarded a federal grant from the National Cancer Institute (NCI) to support a joint cancer genomics data center for the research and clinical interpretation of tumors. The grant will provide funding of $490,000 per year over the next five years.
The WCM-NYGC center will perform computational analyses examining DNA and RNA to understand the role of different mutations and to assess their clinical relevance in treating cancer. It is one of 11 specialized genomic data centers nationwide selected to lead the next phase of The Cancer Genome Atlas (TCGA), an initiative between NCI and the National Human Genome Research Institute, which has generated comprehensive, multi-dimensional maps of key genomic changes in 33 types of cancer. The TCGA’s cancer genomics database, comprised of more than two petabytes of genomic data, has been made publicly available and is helping the cancer research community improve the prevention, diagnosis, and treatment of cancer. By joining this national network, researchers at WCM and NYGC will gain early access to newly produced genomic data, as well as cutting-edge genomic analyses and methods.
The WCM-NYGC multidisciplinary team will be led by co-principal investigators Olivier Elemento, an associate professor of physiology and biophysics, associate director of the and head of the Caryl and Israel Englander Institute for Precision Medicine’s computational biology group at Weill Cornell Medicine; Mark Rubin, director of the Englander Institute for Precision Medicine and the Homer T. Hirst III Professor of Oncology in Pathology at Weill Cornell Medicine; and Michael Zody, senior director of computational biology at NYGC. The investigators have a broad range of complementary experience in cancer genomics — Elemento and Zody in bioinformatics and computational biology, and Rubin in molecular pathology.
“This is a very exciting collaboration between two outstanding institutions with complementary expertise,” Elemento said in a written statement. “The NYGC brings major computational infrastructure strengths and a world-class team of computational biologists. Weill Cornell Medicine brings extensive experience in the clinical interpretation of cancer genomes. It’s a perfect match.”
The goal of this joint center is to obtain new knowledge to understand the correlations between mutations and patient data for research and clinical cancer genomics. The aims of the research are: to analyze mutations to predict patients’ responses to immunotherapy, to facilitate identification of mutations that are driving disease and enabling cancer cells to grow, and to study the role of mutations involving large portions of chromosomal abnormalities
The team has already developed several analytical computer programs that interpret various types of mutations frequently found in cancer genomes and is poised to run these tools on data provided by the TCGA initiative. Over the course of the grant, researchers will develop complementary software and methods designed to improve functional and clinical interpretation of tumor profiles. This collaborative research will utilize Weill Cornell Medicine’s expertise in clinical genomics demonstrated by the first New York State-approved whole exome sequencing test and leverage NYGC’s unique computational infrastructure with more than 5,000 cores and 10 petabytes of storage and data management expertise.
