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Building Tiny Biocompatible Batteries with Heart-Defibrillating Power
Dec 04 | Bio-IT World | In a paper published last week in Science, researchers from the University of Oxford, UK, demonstrate how microprocessors can be created from soft, biocompatible, nanoliter-scale hydrogel droplets. This work builds on a study published last month in Nature Chemical Engineering introducing poppyseed-sized droplet batteries that can be used to power such systems for various bionic and biomedical applications. More -
Barcelona Research Institutions Launch Joint Program on Evolutionary Medical Genomics
Dec 03 | Bio-IT World | Three research institutions in Barcelona have teamed up to launch the world’s first Joint Program on Evolutionary Medical Genomics. The initiative, launched last month at an inaugural symposium in Barcelona Biomedical Research Park (PRBB), is a collaboration between the Centre for Genomic Regulation (CRG), the Department of Medicine and Life Sciences at the Universitat Pompeu Fabra (UPF), and the Institut de Biologia Evolutiva More -
Follow the Money: Seaport Therapeutics Glyph Platform, Pathos AI Expansion, More
Nov 26 | Bio-IT World | Seaport nets funds for its Glyph technology platform; Pathos AI plans to accelerate its AI-powered drug development platform; Alentis Therapeutics pursues antibody drug conjugates; and more. More -
Answer ALS, Cedars-Sinai Collaboration, Single-Cell Protein Profiling, ChapsVision Acquires Sinequa, More
Nov 25 | Bio-IT World | Answer ALS and Cedars-Sinai have announced the completed availability of the largest ALS patient-based induced pluripotent stem cell and bio data repository; Scale Biosciences and Revvity’s business, BioLegend, announced the availability of a first-of-its-kind TotalSeq Phenocyte single-cell protein profiling solution that supports customers by more easily identifying and characterizing rare cell subtypes; ChapsVision has acquired Sinequa; and more. More -
How Digital Chemistry Will Improve Cross-Functional Collaboration In The Biopharma Industry
Nov 22 | Bio-IT World | Digital chemistry is the term given to recent developments in using digital control and big data approaches for designing molecules, optimizing and controlling chemical reactions, and performing complex chemical processes under digital control with sensor feedback. A fundamental development in digital chemistry is the evolution of the concept of chemputation, which allows chemical reactions to be easily done robotically using a general purpose programming language for chemical synthesis. More -
‘Secret Shares’ of Patient Health Data Enable Secure Multiparty Research
Nov 20 | Bio-IT World | Scientists in Europe collaborated on the first international-level clinical study using secure multiparty computation (MPC), which enabled cross-border cooperation without sharing any personalized health data. The cryptographic method traces back to the late 1970s but has been “severely underused” up until now because it’s computationally complex and few data security experts are familiar with the technology. More -
Recursion, Novo Nordisk Release New Chemistry Foundation Model
Nov 19 | Bio-IT World | In a paper published last week in Nature Communications, teams from Recursion and Novo Nordisk created a new foundation model for chemistry called MolE. Benchmarked for absorption, distribution, metabolism, excretion, and toxicity (ADMET) using the Therapeutic Data Commons, MolE outperformed previous models. More -
Much Like a Crime Scene, Cancer’s Evolution Can be Reconstructed
Nov 14 | Bio-IT World | Investigators at Weill Cornell Medicine have combined several powerful technologies to reconstruct how cancer spreads from the prostate to metastatic sites elsewhere in the body. Bioluminescence imaging, CRISPR/Cas9-based barcoding, and innovative computational methods for tracing the movement of cancer from tissue to tissue were used in creating a roadmap revealing the small number of aggressive cells that seed cancer’s often deadly migration. More -
Blueprint of the Human Spliceosome Could Help Find Cancer’s Achilles’ Heel
Nov 13 | Bio-IT World | The spliceosome, the cellular machinery that catalyzes the process of splicing in genes, was discovered nearly five decades ago and has been successfully leveraged in the development of therapies for rare diseases such as spinal muscular dystrophy where concerns about side effects tend to be secondary to correcting the underlying pathology. The question now is how to move the strategy to more complex diseases involving more than a single gene and splicing mutation. More -
New Diagnostic Tool for Identifying the Effects of Antifibrotic Therapy in Breast Cancer
Nov 12 | Bio-IT World | In recent research, scientists at the University of Arizona have developed a diagnostic tool, the MeCo Score, which evaluates metastatic risk in early-stage breast cancer by analyzing how cancer cells respond to the stiffness of surrounding tissue. This tool leverages RNA sequencing data from tumor samples to identify a "mechanical conditioning" (MeCo) signature, giving insights into cancer cell adaptations within the tumor microenvironment. More
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