Alfa Chemistry Expands Selection of Click Chemistry Reagents: DBCO, BCN, and Tetrazines Included

February 22, 2024

Alfa Chemistry, a leading chemical supplier and service provider, has recently announced the expansion of their selection of click chemistry reagents. This development aims to better serve the needs of researchers and scientists working in the field of click chemistry, a powerful method for assembling complex molecular structures quickly and efficiently.


Click chemistry has gained significant attention and popularity in recent years due to its versatility and reliability. It allows researchers to build new molecular entities by selectively linking small building blocks together. This efficient and highly modular approach has applications in a wide range of fields, including drug discovery, materials science, and bioconjugation.


Alfa Chemistry's expanded range of click chemistry reagents now includes DBCO, BCN, and Tetrazines. These reagents are vital components for successful click reactions and enable the formation of stable covalent bonds between molecules. Each reagent offers unique properties and advantages, making them valuable tools for researchers across various disciplines.


DBCO (dibenzocyclooctyne) is a click chemistry reagent that has gained significant recognition for its rapid reaction kinetics and biocompatibility. Its small size and lack of rearrangement make it an ideal choice for biomolecule labeling and bioorthogonal chemistry applications. DBCO reacts selectively with azides, providing researchers with a robust and efficient click chemistry tool. There are hundreds of DBCO chemicals available at Alfa Chemistry, including: Methyltetrazine-PEG12-DBCO (CAS 2183440-28-8), m-PEG4-DBCO (CAS 2228857-36-9), Cy5-DBCO (CAS 1564286-24-3), TAMRA-PEG4-DBCO (CAS 1895849-41-8), ICG-alkyne (CAS 1622335-41-4), etc.


BCN (bicyclononyne) is another essential click chemistry reagent now offered by Alfa Chemistry. Known for its exceptional reaction kinetics, BCN allows for fast and selective reactions with tetrazines. This reagent has become increasingly popular in bioorthogonal chemistry, particularly in the field of antibody-drug conjugates (ADCs), a promising class of therapeutics that combines the targeting ability of antibodies with the potency of cytotoxic drugs.


Tetrazines, on the other hand, serve as highly reactive dienophiles in inverse-electron demand Diels-Alder reactions with strained alkenes. This reaction is extremely powerful and can lead to the formation of covalent bonds at near diffusion-limited rates. Tetrazines have proven to be valuable tools in bioorthogonal chemistry and bioconjugation, enabling the specific and efficient labeling of biomolecules.


By including these click chemistry reagents in its product range, Alfa Chemistry aims to provide researchers with a comprehensive selection of high-quality tools to accelerate their scientific discoveries. The company is known for its commitment to providing customers with exceptional service, ensuring the quality and purity of their products.


Alfa Chemistry's expanded range of click chemistry reagents is now available for purchase through their online platform. The company also offers personalized technical support to assist researchers in selecting the most suitable reagents for their specific applications.


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About Alfa Chemistry

Scientists and researchers in academia, pharmaceutical companies, and research institutions can now benefit from Alfa Chemistry's extensive collection of various chemicals, reagents, and materials. More recently, researchers and scientists now have access to a broader range of high-quality click chemistry reagents to advance their studies and discoveries. With unwavering efforts, Alfa Chemistry continues to be at the forefront of providing innovative solutions to the challenges faced by researchers in diverse scientific fields.