Zymo Research Sets New Standard in NGS Library Prep with Endura™ Tn5 Transposase

July 20, 2025

IRVINE, Calif., (July 21st, 2025) – Zymo Research, a leader in biotechnology innovation, announces the launch of Endura™ Tn5 Transposase, a next-generation advancement in Tn5-based technologies for next-generation sequencing (NGS) library preparation.

“Endura™ has been specifically developed for unprecedented stability and consistent performance in NGS-based applications”, said Dr. Joshua Misa, R&D Scientist at Zymo Research.

Since the development of a hyperactive Tn5 transposase, it has become a widely used tool in NGS libraries. It enables simultaneous DNA fragmentation and adapter tagging in a single step – a process that dramatically simplifies library preparation. However, despite advancements in enzyme activity and efforts to reduce bias, researchers continue to face challenges with enzyme instability and inconsistent fragmentation results.

Endura™ Tn5 Transposase address these challenges head-on, outperforming competitors in head-to-head stability and performance assays. It offers:

  • Superior shelf-life
  • Lot-to-lot reproducibility
  • Standardized unit definition for precise enzyme input and consistent results

With Endura™ Tn5, Zymo Research delivers unmatched performance and reliability, setting a new benchmark for Tn5-based NGS workflows.

Zymo Research leverages its state-of-the-art fermentation and bioprocessing capabilities at its US-based facilities in Southern California to develop and manufacture high-quality enzymes. Endura™ Tn5 Transposase is the latest addition to Zymo Research’s enzyme portfolio, driving advancements and setting new standards in molecular biology research and applications.

For more information on Zymo Research's Endura™ Tn5 Transposase please check out Endura™ Tn5 Transposase.

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About Zymo Research Corp.

Zymo Research, a privately owned biotech company founded in 1994, is a global leader in molecular tools for life sciences. Driven by the principle "The Beauty of Science is to Make Things Simple," Zymo Research is dedicated to developing innovative solutions that address complex scientific challenges.

Known also as The Epigenetics Company, Zymo Research offers a comprehensive range of technologies, including solutions for sample collection, DNA/RNA purification, library preparation, microbiomics, transcriptomics, epigenomics, genomics, and Next-Generation Sequencing (NGS) services.

In addition to its cutting-edge technologies, Zymo Research is committed to sustainability. By engineering environmentally friendly solutions, the company strives to reduce waste and contribute to a more sustainable future through scientific innovation.

For more information, please visit www.zymoresearch.com and follow on Facebook, LinkedIn, X (Twitter), and Instagram.