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Creative Proteomics Announces Its Newly-developed Proteomics Services for Protein Scientists

April 15, 2019

SHIRLEY, NY, UNITED STATES - Apr 16, 2019 - Creative Proteomics, a leading supplier in drug development services, has recently released its newly-developed proteomics services to researchers. The service ranges include five: AQUA analysis service, iTRAQ labeling service, label free quantitation service, SILAC mass spectrometry service, and TMT proteomics service.


Absolute quantification, also known as AQUA analysis, is a targeted quantitative proteomics technology with powerful efficacy and is increasingly used in a variety of quantitative proteomics studies. The AQUA strategy is used for absolute quantification (AQUA) of proteins and their modified states. The synthesized peptide acts as an ideal internal standard together with the incorporated stable isotope to mimic the natural peptide formed by proteolysis. These synthetic peptides can also be prepared by chemically identical covalent modifications (e.g., phosphorylation, methylation, acetylation, etc.) to naturally occurring post-translational modification. The absolute level of proteolytic and post-translationally modified proteins is then accurately and quantitatively measured using such AQUA internal standard peptides by using selected reaction monitoring assays in a tandem mass spectrometer. Advances in biological mass spectrometry have led to the development of a number of strategies for quantifying intracellular protein expression levels. In addition to the measurement of protein expression accomplished by differentially incorporating stable isotopes into cellular proteins, absolute quantification is a useful method in proteomic analysis. 


Relative quantification of proteins that find biomarkers in complex mixtures by mass spectrometry can be easily and quickly achieved using iTRAQ labeling technology. iTRAQ is ideal for comparing normal, diseased and drug treated samples, time course studies, biological replicates, and providing relative quantification. Creative Proteomics offers iTRAQ protein quantification services for unbiased, non-targeted biomarker discovery.


Label free quantification is a method in mass spectrometry that aims to determine the relative amount of protein in two or more biological samples. Unlike other protein quantification methods, label-free quantification does not use compounds containing stable isotopes to chemically bind and thus label proteins. Creative Proteomics provides a label-free approach for relative and absolute quantification, a fast and low-cost alternative to other quantitative proteomics methods.


SILAC-based quantitative proteomics (SILAQ) is an innovative technique for high-throughput quantitative analysis of large protein complexes, protein-protein and protein-small molecule interactions. Creative Proteomics' SILAC mass spectrometry service provides an unbiased strategy that reveals the effects of inhibitors or other perturbations on protein dynamics and cell distribution. It can also be used as a sensitive and efficient method for determining specific interaction partners for proteins in cells.


The isobaric tag TMT (tandem mass tag) has up to 11 tags that can be used to label almost any peptide or protein sample. TMT can reuse analysis, effectively utilize instrument time and further control technology changes. Because it is capable of up to 11 samples, TMT proteomics is widely used to quantify protein biomarker discovery. TMTzero, TMTduplex, TMTsixplex, TMT10plex and TMT11plex reagents share the same structure, allowing efficient conversion from method development to multiple quantification.


 “Creative Proteomics is a professional biotech company specializing in providing Proteomics services. State-of-the-art equipment, highly trained and experienced staff, as well as reference methodologies are utilized to enable us to deliver consistent and high-quality data with cost-efficiency. Based on highly experienced and knowledgeable in the application of wine analysis, Creative Proteomics can provide fast turnaround, clear concise written reports, and custom service to help customers resolve your analytical and technical challenges.” said Dr. Charlie.


About Creative Proteomics

Creative Proteomics, as an experienced proteomics, metabolomics, and bioinformatics services supplier, has been equipped with advanced technologies to meet the growing needs of researchers and scientists in proteomics and metabolomics related researches.


Address: 45-1 Ramsey Road, Shirley, NY 11967, USA