ProQinase: Syngeneic mouse models as a tool to study immune modulatory effects of cancer therapeutics
Every cancer treatment has the potential to induce a stimulatory or inhibitory effect on the immune response to a tumor. Scientific knowledge about the significance of the immune system for tumor eradication during conventional treatment is growing quickly, and an increasing number of immune-modulating drugs are entering clinical trials for cancer treatment. This necessitates investigating these drugs in the presence of an intact immune system, and syngeneic tumor models are the ideal tool to achieve this. In addition to our many xenograft mouse models, we established several syngeneic tumor models, which we thoroughly characterized with respect to immune phenotyping and response to immune checkpoint inhibition. Four of them are introduced in this white paper