• Pharma-Diagnostics Lockstep: How Two Industries Can Work Together for Precision Medicine

    Bio-IT World | Sarah Hersey, VP of Precision Medicine at Bristol Myers Squibb, gave a balanced view of the challenges and opportunities facing precision medicine in her keynote address at the Molecular & Precision Medicine Tri-Conference in San Diego this week. After her presentation she was joined by others in the space to talk about the future for diagnostics and precision medicine.

    Mar 7, 2023
  • Therapeutic Targets For MS Found In The Gut

    Bio-IT World | Neuroscientists at the University of Virginia have succeeded in alleviating the harmful inflammation of multiple sclerosis in a mouse model of the disease by modulating the gut microbiome to disable a key immune regulator known as aryl hydrocarbon receptor.

    Mar 2, 2023
  • Forged in Steel, Exscientia Brings New Processes to Drug Development

    Bio-IT World | Andrew Hopkins, CEO and Executive Director of Exscientia, speaks with host Stan Gloss of BioTeam about Exscientia’s machine learning-based and model-driven approach to drug design, the connection between knowledge and efficiency in drug optimization projects, and its fourth platform-designed drug launch into the clinic.

    Feb 28, 2023
  • Oxford Nanopore, Tecan Launch Automated NGS Library Prep Workflow

    Bio-IT World | Oxford Nanopore Technologies and the Tecan Group announced their collaboration on an automated NGS library preparation workflow, and released a technical note outlining a proof-of-concept use case where the Oxford Nanopore’s Ligation Sequencing Kit XL V14 processing multiple DNA samples on the Tecan DreamPrep NGS achieves high yield and raw read sequencing modal accuracy of Q20 (99%) and above.

    Feb 28, 2023
  • Oxford Nanopore Extends Collaboration With UPS Healthcare, Illumina Delivers High Throughput Sequencing System to the Broad Institute, More

    Bio-IT World | Advanced machine learning provides objective tumor response assessments and unlocks novel biomarkers to predict patient outcomes; a comprehensive single-cell multi-omic solution enables the simultaneous exploration of the whole genome and whole mRNA transcriptome from the same single cell; cutting-edge generative AI models, proprietary wet-lab technologies, and a leading cancer biospecimen repository and molecular database identify new therapeutic candidates at accelerated speeds; and more.

    Feb 23, 2023
  • Gut Microbiome Implicated In Endometriosis

    Bio-IT World | The gut microbiome has for the first time been linked to a causal role in endometriosis. Up to now, efforts to investigate the contributing factors have been focused primarily on genetic changes or epigenetic disorders and yet understanding of the underlying pathology remains largely a mystery.

    Feb 22, 2023
  • Follow the Money: Waters Acquires Wyatt to Build Bioanalytical Characterization Business, NIAID Establishes Immunology Data Analysis Institute, More

    Bio-IT World | Funding for a proprietary AI-driven 3D structure engine for RNA drug discovery, unique binary assembly technology to deliver accurate, gene-length DNA in a benchtop instrument, a national institute that develops artificial intelligence systems to identify and assist young children with speech and language processing challenges, and more.

    Feb 21, 2023
  • Exploring the Changing Approach to Drug Safety

    Bio-IT World | Pharmacovigilance plays a critical role in drug safety. Pharmaceutical companies monitor newly licensed drugs, evaluate previously unreported adverse reactions, and balance drug effectiveness. We are evolving from manual pharmacovigilance to an era of precision pharmacovigilance, where a personalized approach to drug safety helps maximize the reach of new drugs and minimize adverse events.

    Feb 17, 2023
  • Natural Language Processing Designs Original Proteins From Scratch

    Bio-IT World | Using a natural language processing program developed by Salesforce Research, scientists have engineered artificial enzymes that look and fold just like natural proteins and function just as well. The artificial intelligence tool, called ProGen, allows information from the evolutionary record of multiple protein families to generate new enzymes that could prove therapeutically useful.

    Feb 16, 2023
  • New Zinc-Finger Technology Makes For Faster, Better Genetic Editing

    Bio-IT World | CRISPR-based approaches that rely on the enzyme Cas9 to cut DNA at precise locations has been the darling of genetics research over the past few years. The revolutionary gene-editing system can also produce a lot of off-target activity. And when delivered via adeno-associated virus vectors, Cas9 occupies so much space that little room is left for any other therapeutic cargo that might be needed.

    Feb 14, 2023
  • Bioassays Have An Integration Problem: Collaboration Will Be Key To Making Them FAIR

    Bio-IT World | Whilst life science companies have come to recognize data as their greatest asset, it is also their greatest challenge. Much of data is siloed in different formats and locations, making it difficult to discover, query, and share—rendering data essentially unusable. FAIR data must be rolled out across the entire industry if companies want to accelerate R&D and enable scientific queries to be answered more rapidly.

    Feb 10, 2023
  • Biomedical Research Experts Reach Consensus on Open Science Practices to Monitor Institutions Worldwide

    Bio-IT World | A group of 80 research stakeholders convened to determine the best biomedical open science practices and create a fully automated dashboard to monitor their implementation. The team’s efforts will be used to improve research quality and foster innovation in the biomedical space.

    Feb 9, 2023
  • Deepcell Releases Sample Datasets to Highlight Morphology-Driven Data

    Bio-IT World | Deepcell, a pioneer in AI-powered single cell analysis to fuel deep biological discoveries, has released three datasets, available online, to enable researchers to explore novel high-dimensional morphology data. The datasets were generated on Deepcell’s high-throughput platform, comprised of imaging and sorting instrumentation, AI models, and a software suite.

    Feb 7, 2023
  • The Carbon Footprint Impact of Cloud Solutions

    Bio-IT World | While those in the life sciences appreciate the importance of curbing greenhouse gas emissions and the pressing impact of global warming, actionable steps toward going green have yet to permeate all facets of cloud computing research. As such, the current state of affairs in bioinformatic computing is not particularly green.

    Feb 3, 2023
  • 3D Spatial Proteomics Provides View Of Diseases At Early Stages

    Bio-IT World | Researchers in Germany have developed a series of innovative solutions for probing the body more broadly and deeply for early pathological signs of diseases ranging from metabolic disorders and neurodegenerative diseases to cancer. Their novel technology, dubbed DISCO-MS, does spatial proteomics in three-dimensional (3D) intact specimens using a combination of whole-organ and whole-organism clearing and imaging, deep-learning-based image analysis, robotic tissue extraction, and ultrahigh-sensitivity mass spectrometry.

    Feb 2, 2023
  • Retinal Organoid-Derived Neurons to Potentially Cure Degenerative Eye Disease

    Bio-IT World | A new study published in the Proceedings of the National Academy of Science demonstrates the potential for lab-grown retinal neurons to reestablish synaptic function and cure neurodegenerative eye disease, according to researchers from the University of Wisconsin–Madison.

    Jan 31, 2023
  • Take the DNA Delorean: The Promise of Large Language Models in Genomics

    Bio-IT World | Information directly from DNA to understand RNA's and human proteins' downstream structure describes how our cells function in clear linguistic terms. Today, large language models demonstrate remarkable abilities to interpret, translate, summarize, and generate human languages. Now, we are finally generating the amount of data required to train such models in the language of biology.

    Jan 27, 2023
  • Microsoft Applies AI to Digitial Cancer Pathology Imaging, World’s First Next-Generation Single-Molecule Protein Sequencing Platform, More

    Bio-IT World | A Salmonella-based bactofection platform to deliver RNA payloads to treat cancer patients; tRNA therapeutics capable of overcoming genetic errors to treat genetic diseases and cancer; the Jackson Laboratory enters an expansive and exclusive intellectual property licensing agreement across six areas of human health; and more.

    Jan 26, 2023
  • How Recursion Hopes to Harness the Big Picture View to Understand Biology’s Landscape

    Bio-IT World | In the latest episode of Trends from the Trenches podcast, host Stan Gloss of BioTeam sits down with Chris Gibson, co-founder and CEO of Recursion, to talk about Recursion’s mission to decode biology, radically improve lives, and set big goals to innovate across every stage of drug discovery.

    Jan 24, 2023
  • Follow the Money: University of Chicago Funds Biotech Accelerator, Breakthrough Tankless Inhaled Nitric Oxide Delivery System, More

    Bio-IT World | Funding for new therapeutic targets for a proprietary genetic medicines pipeline fueled by an automated discovery engine and versatile gene-editing toolbox, an in vivo engineered cell therapy platform for immuno-oncology genomic medicines, advanced therapeutic nucleic acids manufacturing, and more.

    Jan 24, 2023