• AI, Hybrid Cloud and Quantum Computing Seen by IBMs Krishna as Shaping IT

    Bio-IT World | IBM CEO Arvind Krishna sees AI, hybrid cloud computing, and quantum computing as setting the future of the IT industry.

    Nov 23, 2020

  • New Virtual Reality Tool, Domestic Cats are SARS-CoV-2 Carriers, Combination Therapy Advances: COVID-19 Updates

    Bio-IT World I St. Jude discovers hyperinflammatory pathway, hepatitis C drugs are potential treatment, non-human primate model identifies features of virus, IL-10 production is a marker for severity, recommendations on re-use of data, molecular structure of key E-protein, and early antibody evolution predicts outcomes. Plus: Disrupting SKI complex prevents viral replication, why COVID-19 spares children, and how smoking causes more severe infection.

    Nov 20, 2020

  • Behind the VC Curtain: Investors Talk About Post-COVID Trends and the ‘New’ Healthcare Tech

    Bio-IT World | COVID-19 is switching the risk paradigm for biotech and pharma. It’s too risky, now, not to do something digital. It’s driving changes in investing as well. A recent panel discussion explored how venture capital and new tech companies evaluate technology, invest cash, and plan to move forward.

    Nov 19, 2020

  • Molecular Tagging System With Real-World Potential

    Bio-IT World | A decades-old technology initially used to hide secret messages in dots of DNA—along with Oxford Nanopore sequencing—could get a reboot as a tracking system for commodities that might be too small or numerous for tagging with QR codes or radio-frequency identification, such as experimental drugs and controlled substances.

    Nov 17, 2020

  • Illumina Announces P3 High-Output Flow Cell, NextSeq 1000

    Bio-IT World | Illumina has announced the commercial availability of the P3 high-output flow cell, offering 1.1 billion reads in a single sequencing run. The company also announced the commercial availability of the NextSeq 1000.

    Nov 13, 2020

  • New Rhesus Macaque Model, Six SARS-CoV-2 Strains, the Structure of Dexamethasone with Serum Albumin: COVID-19 Updates

    Bio-IT World | A look at how COVID-19 patients fare after recovery, Mount Sinai’s new ML model analyzes EHRs, overlapping genes in viruses, conferred immunity from other coronaviruses, and a picture of RNA-RNA interactions. Plus a new Intel system at LLNL for COVID-19 research, Baylor’s coronavirus curriculum, and a recommended vaccine distribution framework.

    Nov 13, 2020

  • Big Data, Supercomputing Deployed For Disease Risk Prediction Models

    Bio-IT World | The Department of Veterans Affairs (VA) and the Department of Energy (DOE) have teamed up to develop disease risk prediction models using deep learning, according to Ravi Madduri, a computer scientist at the DOE’s Argonne National Laboratory and co-lead of the collaboration.

    Nov 12, 2020

  • Fall New Products, News From DNAnexus, Immunai, Thermo Fisher, More

    Bio-IT World | New products, collaborations and deployments from the past two months from Quantum, Mission Bio, Seqster, Takeda, Optibrium, the Pistoia Alliance, Caris Life Sciences, Genomenon, and more.

    Nov 11, 2020

  • Bryn Roberts: Reflections on Pharma’s Scientific Computing Journey

    Bio-IT World | Pharma has had a long history with data. Of course, it wasn’t always digital but there’s always been a data trail. We asked Bryn Roberts from Roche for insights gleaned from his nearly three decades in the pharma industry, mainly in roles related to data science, information technology, and automation. Generating and collecting data has never really been a problem, he said. Managing it, however, has always been a challenge.

    Nov 10, 2020

  • Synthetic Nanobody Potential Treatment, Red Marrow Main Target, Europe Source Of Spread: COVID-19 Updates

    Bio-IT World I Isolated cannabis compounds decrease cytokines, spike protein disrupts blood-brain barrier, aprotinin potential treatment, D614F mutation made virus more contagious, seven forms of disease identified, and new nanoparticle vaccine a promising candidate. Plus: Cornea of the eye may be resistant, propranolol reduces inflammation, autoimmune antibody culprit for blood clots, and lung damage found in ‘long COVID’.

    Nov 6, 2020

  • Setting Your Group Up For Data Governance Success

    Bio-IT World | Data governance is a somewhat fluid term, encompassing all aspects of making sure our data are accurate, consistent, current, and secure. Successful data governance relies on input from scientists, IT teams, and executives, and it must remain flexible as stakeholders change, business interests evolve, and collaborations mature.

    Nov 5, 2020

  • Real Progress In Crowdsourcing Scientific Tasks To Gamers

    Bio-IT World | Gaming and science—two seemingly incompatible areas of activity—have come together nicely in the case of citizen science games such as Foldit, Phylo, and Borderlands Science, as reported by academics close to the action who presented at the recent Bio-IT World Conference & Expo Virtual. The games are all played online, involve analyzing large sets of data, and endeavoring to solve real scientific problems. And players get credit individually (when willing) or as a crowd when findings appear in scholarly, peer-reviewed publications.

    Nov 4, 2020

  • Mini-Lungs In A Dish, Airway Stem Cells, Evolution of Virus Mutations: COVID-19 Updates

    Bio-IT World I Neutrons chart atomic map of COVID-19’s viral replication, Organs-on-Chips technology, coronaviruses mimic proteins that control blood coagulation and inflammation, therapeutic effects of Chinese herbal medicine, crystal structure identified on SARS-CoV-2 papain-like protease, and potent antibody isolated. Plus: NIH researchers discover key pathway in lysosomes for coronaviruses exit, deep learning models to target SARS-CoV-2 main protease, RBD nanoparticles may be effective vaccine, predicting outbreaks, virus may ‘hide’ in asymptomatic people, and NYC outbreak linked to Europe.

    Oct 30, 2020

  • Follow the Money: Microbiome, ‘Omics, Vaccine Patches

    Bio-IT World | Money for oral microbiome drugs, ‘omics, a biology plus technology transistor, digital biomarker platform, a vaccine patch that doesn’t require refrigeration, and more.

    Oct 28, 2020

  • Illumina Launches DRAGEN V3.7, Talks ML, Truth Challenges, All Of Us

    Bio-IT World | Illumina is launching version 3.7 of its DRAGEN bio-IT platform this week, Rami Mehio, Vice President, Bioinformatics and Instrument Software at Illumina, told Bio-IT World last week. The newest release will include DRAGEN for Single Cell RNA, unique molecular identifier (UMI) support including UMI-aware small variant calling, CYP2D6 genotyping, and accuracy gains in both germline variant calling and tumor-only analysis.

    Oct 27, 2020

  • Clinical Data Visualizations at BMS Merge Trial and Real-World Data

    Bio-IT World | The probability of success is low in early drug discovery and gets progressively more expensive on the journey to marketing approval by the Food and Drug Administration (FDA). To “fail early and fail often” has thus become the mantra of medicine developers needing to direct resources to the candidates most likely to triumph, says Philip Ross, director of translational bioinformatics data science at Bristol-Myers Squibb (BMS). Only 9.6% of drugs that make it to phase I trials ever get FDA approved.

    Oct 26, 2020

  • ‘High-Risk, High-Reward’ Approach To Finding Alzheimer’s Disease Treatments

    Bio-IT World The quest to find new medicines for Alzheimer’s disease (AD) may finally make some headway, thanks to a Target Enablement to Accelerate Therapy Development for Alzheimer’s Disease (TREAT-AD) project that is taking a “high-risk, high-reward” approach to diversifying the drug development pipeline, according to Lara Mangravite, president of Sage Bionetworks. The Seattle-based nonprofit is partnered with Emory University and the Structural Genomics Consortium (SGC) on the initiative.

    Oct 19, 2020

  • FOXP3 Protein Inhibited, Blocking Factor D Protein May Prevent Inflammatory Response, App Crowdsources Drug Candidates: COVID-19 Updates

    Bio-IT World I Cloud-based tool, IDseq, allows tracking of emerging pathogens, scientist who discovered SARS captures detailed look of immune system response to COVID-19, SARS-CoV-2 may become endemic, ORF3B identified as viral factor that impairs immune response, age is an independent factor to virus susceptibility, group of 80 researchers warns against herd immunity approach, high dose favipiravir had significant effect on preventing and treating virus in hamster model, REGN-COV2 antibody ‘cocktail’ offers protection in pre-clinical trial on macaques. Plus: SARS-CoV antibodies effectively neutralize SARS-CoV-2 infection in cultured cells, international open access database aims to reduce duplication of ongoing COVID-19 research and more.

    Oct 15, 2020

  • Proving The Value Of Preventive Genomics

    Bio-IT World | The Bio-IT World Conference & Expo closed out with a plenary keynote presentation on preventive genomics by Robert Green, M.D., professor of medicine at Harvard Medical School and a physician-scientist who directs the G2P Research Program at Brigham and Women’s Hospital and the Broad Institute. Data-sharing difficulties were a recurring theme at this year’s conference but, as the COVID-19 Host Genetics Initiative has demonstrated, it is possible to combine genomic data to rapidly explore markers of disease, he says.

    Oct 14, 2020

  • Researcher-Driven Data Stewardship, Storage: Trends from the Trenches 2020

    Bio-IT World  | On its 10th anniversary, the annual Trends from the Trenches presentation from Chris Dagdigian, co-founder and principle consultant of BioTeam, and friends had lost none of its characteristic candor and punch—even in a virtual environment and even as Dagdigian successfully continued to limit his own speaking time.

    Oct 13, 2020