• ‘Federated Analysis’ Helps Fill Genetic Risk Knowledge Gap On BRCA Genes

    Bio-IT World | A significantly heightened risk of breast cancer has two well-known culprits—mutations to the tumor suppressor genes BRCA1 and BRCA2—but more than 40% of the time they are black-box “variants of uncertain significance.” Using a new data-sharing innovation known as federated analysis, however, an international team of researchers has categorized 16 of these uncertain variants as benign or likely benign so their carriers may be able to have their clinical risk of disease managed properly and avoid the risk of invasive and irrevocable surgeries.

    Jun 14, 2022

  • Biotech Industry Leaders Give Advice to Earlier-Career Scientists

    Bio-IT World | Over the past two years, Stan Gloss, founding partner at BioTeam, has been sitting down with leaders in pharma and biotech for our Trends from the Trenches column and—more recently—the Trends from the Trenches podcast. They have been wide-ranging conversations covering everything from digital transformation at big pharma to All of Us and population genomics, data-driven cancer genomics to AI/ML models in drug discovery.

    Jun 9, 2022

  • Genetic Control Of Autoimmune Disease Mapped To Cellular Level

    Bio-IT World | The pioneering OneK1K study in Australia has identified an immune “fingerprint” of seven autoimmune disorders using single-cell RNA sequencing (scRNA-seq). The general framework, which combines the scRNA-seq data with genotype data to classify individual cells, can be applied to many different diseases.

    Jun 8, 2022

  • Building a Tech-Enabled Drug Discovery Pipeline at AstraZeneca

    Bio-IT World | Innovative Practices Award | AstraZeneca is using technology to speed and improve drug discovery at every step of the process, explained Anna Berg Asberg, global VP of R&D IT, last month in her presentation at the Bio-IT World Conference and Expo outlining AstraZeneca’s Bio-IT World Innovative Practices Award-winning project.

    Jun 7, 2022

  • The Role of AI in Precision Health Explored at Bio-IT World Conference

    Bio-IT World | At the Bio-IT World Conference & Expo last month, several sessions explored ways AI is transforming oncology diagnosis, research, and care delivery. Speakers from the National Cancer Institute, Tempus Labs, The Ohio State University, IQVIA, Pangaea Data, University of Illinois Cancer Center, Stable Solutions and more discussed how far we’ve come, and where our next challenges lie.

    Jun 7, 2022