• New Tactic Proposed To Find Drugs For Alzheimer’s Disease

    Bio-IT World | A new method to screen drugs for treating Alzheimer’s disease could significantly improve the odds of therapeutic success by analyzing causal mechanisms in human neurons, according to Shankar Subramaniam, professor of bioengineering at the University of California (UC) San Diego. The plan now is to extend the work to organoids with microglia cells and vasculature, creating “realistic human brain avatars” for better understanding disease endotypes and their response to treatment.

    Mar 10, 2022

  • How to Manage Data as an Asset: Opinions from a Fortune 5 Executive

    Bio-IT World | As Executive Director of Enterprise Data Engineering and Analytics at CVS Health, Saira Kazmi uses her background in computer science and engineering in both academic and industry positions to inform her new role. She learned about the importance of iterative testing under the tightest timelines from the industry and got a first-hand view of the engineering rigor required to enable bioinformatics from her academic career. Now she is focused on creating data assets and managing the data life cycle at the enterprise level for a major healthcare player.

    Mar 8, 2022

  • Hormone-Producing Intestinal Cells Could Be Tapped As A Weight-Loss Remedy

    Bio-IT World | An organoid model is being used to flush out what’s behind production of a rare subset of cells in the human intestine and the hormones they manufacture, including four that seem to have the most effect on decreasing appetite.

    Mar 7, 2022

  • Genentech Builds Single Cell Proteomics Platform for Real Time Mass Spec Analysis

    Bio-IT World | Our technical capabilities are becoming increasingly granular, and proteomics is no exception. At the recent Molecular & Precision Med TRI-CON, Christopher Rose reported on how his group within the Microchemistry, Proteomics & Lipidomics department at Genentech where he currently leads the Discovery Proteomics group is working to build a single-cell proteomics platform.

    Mar 3, 2022

  • Cloud IT, Structural Variants, AI for Cancer, More

    Bio-IT World | Structural variant detection in FFPE samples, new federated network for genomic variant surveillance, Element Biosciences’ new acquisitions and collaborations, RNA profiling to predict preterm birth, release of multi-modal mental health dataset, AI in genetic variant analysis for cancer and beta-propeller protein-associated neurodegeneration, and more.

    Mar 2, 2022

  • Follow the Money: ML in Immunology, Virtual Drug Screening; Single-Cell Multi-Omic Sequencing; AI Marketplace

    Bio-IT World | AI and ML in immunological therapeutic development, virtual drug screening, microscope-based rapid pathogen diagnostics, improved genetic variant interpretation, and more.

    Feb 28, 2022

  • IDMP as a Tool for Better Organizational Data

    Bio-IT World | The clock is ticking on implementing the EMA's IDMP standard. With the release of EU IG v2.1, the industry is in the final stages of preparations for optional submission. While regulatory teams have made progress applying guidance to uniquely identify products and standardize information, more work remains to establish a proper data foundation that supports submissions under the new requirements.

    Feb 25, 2022

  • Expert Panel: Next Steps to Achieving Precision Medicine

    Bio-IT World | In the opening plenary panel for the Molecular and Precision Med Tri-Con this week, Robert Green, Brigham and Women’s Hospital, led a group in exploring how genomics, digital health, and more will converge to deliver precision health. He was joined by Megan Mahoney, Stanford University; Jessica Mega, Verily Life Sciences; Sir Mark Caulfield, Barts Life Sciences & Queen Mary University of London; and Lara Jehi, Cleveland Clinic.

    Feb 24, 2022