• More ‘Omics for SARS-CoV-2, Insights into the Spike Protein, Crowdsourcing Questions: COVID-19 Updates

    Bio-IT World | A Canadian team shares a new mechanism of action for remdesivir, data science groups have computed consensomes (gene expression in the virus) and interactomes (potential molecular mechanisms of pathogenesis) and cryoEM images the spike protein. Plus, NIH funding for new vaccines and the Reliable Response Data Discovery consortium takes COVID-19 patient data questions.

    Sep 25, 2020

  • Ecological Modeling Of Gut Microbiome Points To Probiotic Cures

    Bio-IT World Fecal microbiota transplantation (FMT), the idea of using fecal material from a healthy person to treat others who are sick, has been proposed for challenging conditions ranging from inflammatory bowel disease to autism and obesity. But to date, robust evidence from randomized clinical trials exists only for the use of FMT to treat recurrent C. difficile infection.

    Sep 24, 2020

  • The Role of Data Management in Advancing Biology

    Bio-IT World Kjiersten Fagnan had a plan: she would be an engineer, work for a company, and write software all day. But biology is intriguing and now Fagnan is the Chief Informatics Officer at the Joint Genome Institute. She recently spoke with Stan Gloss, founding partner at the BioTeam, about the community challenges around creating and sharing more useful data, and how “human engineering” can help advance biology.

    Sep 21, 2020

  • Sticky Webs, A Tiny Molecular Weapon, Obesity Paradox N/A: COVID-19 Updates

    Bio-IT World New drug targets, reconstructing viral spread and lineage, monitoring mutations, reasons to focus on T-cell responses, DNA webs as culprits of tissue damage, a very tiny neutralizing agent, explaining paradoxical risk in people with obesity and diabetes, and the value of heparan. Plus, a new vaccine candidate heading to human trials, coronaviruses are being profiled, and a deep dive on how SARS-CoV-2 weakens the immune system.

    Sep 17, 2020

  • Targeted Protein Degradation: Why Just Inhibit What Can Be Destroyed?

    Bio-IT World Disease treatment through targeted protein degradation takes a range of approaches: from small molecules similar to thalidomide that act as “molecular glue” degraders to more advanced “beyond rule of 5” proteolysis-targeting chimeras (PROTACs) with bifunctional moieties that encourage protein interaction with its E3 ubiquitin ligase.

    Sep 17, 2020

  • Continuous Software Validation Critical for Balancing Digital Transformation and Compliance

    Bio-IT World  The adoption of cloud technology in the life science industry has become increasingly pervasive as firms move forward with digital transformation initiatives aimed at creating operational efficiencies and delivering the next wave of biomedical innovations. As a result, cloud vendors are playing a more important role than ever before, especially for life sciences companies that produce FDA-regulated products.

    Sep 15, 2020

  • VAST Data Launches LightSpeed Storage Architecture

    Bio-IT World VAST Data has launched its next generation storage architecture, LightSpeed, which combines the light-touch of VAST’s simple NAS appliance experience with leadership-class performance for GPU-based and AI Processor-based computing, taking the guesswork and configuration out of scaling up AI infrastructure.

    Sep 15, 2020