• The Practical, Near-Term Future for Synthetic Biology

    Bio-IT World | Trends from the Trenches | Aoife Brennan left the practice of medicine to explore biotech. Now she leads Synlogic, developing scientific strategy for the company’s practical applications of synthetic biology. Brennan spoke about her career journey and the future of synthetic biology—a preview of her upcoming talk at the Bio-IT World Conference & Expo.

    Sep 9, 2021
  • A Closer Look at Type 1 Diabetes Causal Variants

    Bio-IT World | Researchers from the University of Virginia and the University of Oxford have been tracing the genes responsible for type 1 diabetes for years. The team just published the largest look yet: exploring the genomes of more than 61,000 individuals of diverse ancestry to better understand the genetic underpinnings of this complex disease.

    Sep 7, 2021
  • Follow the Money: Next Gen Oligonucleotides, ML Insights Platform

    Bio-IT World | HealthTech SPAC funding, wearable fitness program for metabolic health disorders, multiple academic grants for dementia research, using AI to watch cells over time, and more.

    Sep 3, 2021
  • New Results from BabySeq, Pharmacogenomic Updates, New Products

    Bio-IT World | Harvard-Israel and Sema4-Avera launch precision medicine partnerships, Rice announces new Genetic Design and Engineering Center, Foundation Medicine partners with Epic, and Amgen and USC provide cryo-TEMs. Plus new products from BioIVT, BD.

    Sep 1, 2021
  • Artificial Intelligence Calculates Anti-Aging Properties Of Compounds

    Bio-IT World | Artificial intelligence (AI) has been paired with one of the simplest of organisms—the nematode Caenorhabditis elegans—to enlighten the scientific community about the physical and chemical properties of drug compounds with anti-aging effects.

    Aug 31, 2021
  • Superbugs and the Flawed Antibiotic Development Model, Alert to a Growing Global Health Risk

    Bio-IT World | After over a year of the coronavirus pandemic, it’s hard to picture another global health crisis emerging, but data indicates bacterial infections could cause the next pandemic, as several known “superbugs” have adapted to resist all available antibiotics. The effects could be highly detrimental if today’s antibiotic development model doesn’t evolve and take priority. Antibiotics typically take an average of 10-15 years to develop and at high costs, roughly 1-2 billion dollars. This is due in part to the long, risky drug development process that has become the standard.

    Aug 27, 2021
  • Discovery on Target: A Deeper Look at 3D Cellular Models

    Bio-IT World | “This field is developing so rapidly. If it has been six months…, you're behind.” That’s how Christopher Austin describes the 3D cellular models research landscape. As the past director for NCATS, the National Center for Advancing Translational Sciences, Chris knows the pace of this research area well. He recently left NCATS to serve as one of Flagship Pioneering’s CEO-Partners.

    Aug 26, 2021
  • Biochip Platform Could Enable Personalized Immunotherapy

    Bio-IT World | Rensselaer Polytechnic Institute and South Korean biotech Medical & Bio Decision Company Ltd. (MBD) are working on turning a biochip into a personalized immunotherapy platform for rapidly screening a wide range of treatment cocktails for individual cancer patients. The platform would be ideally suited for very small tumor biopsy samples.

    Aug 25, 2021
  • NIH Awards $53M for HIV Cure Research for Adults, Children

    Bio-IT World | The National Institutes of Health has awarded approximately $53 million in annual funding over the next five years to 10 research organizations in a continued effort to find a cure for HIV.

    Aug 23, 2021
  • Three Reasons Biopharma Companies Can’t Afford To Miss The Digital Revolution

    Bio-IT World | In the biopharmaceutical industry, there’s no shortage of data—the issue organizations more often face is how to capture data in ways that derive insight from it. Rather than stitching together a patchwork of data from disparate systems after the fact, more emphasis should be placed on capturing data in context, right at the point of execution.

    Aug 20, 2021
  • Ovarian Cancer Chip Model Reveals Drug Repurposing Opportunities

    Bio-IT World | A novel organ-on-a-chip model of ovarian cancer has been used to showcase the sinister activities of tumors, including use of circulating platelets to fuel their growth and undermine treatment with chemotherapeutic drugs. The model also demonstrated the potential of an anti-platelet drug, currently in clinical trials for a different condition: to fight back.

    Aug 17, 2021
  • Unchanging Rules Of Gene Expression Could Improve Drug Approval Odds

    Bio-IT World | Network theory holds that everything is connected—including if the “nodes” are human cells, genomes, proteomes, or transcriptomes. It is “pure, algorithm-run precision math,” and it could be an entirely new approach to big data science that could erase the declining odds that a drug entering clinical studies will exit a winner.

    Aug 13, 2021
  • Spanish Team Builds Neural Network to Predict Small Molecule Characteristics

    Bio-IT World | A team of researchers in Barcelona have gathered bioactivity information for a million molecules using deep machine-learning computational models and a database of experimental results. Both the experimental results and the machine learning tool are available to the community at bioactivitysignatures.org.

    Aug 11, 2021
  • AI in Healthcare: Lessons Learned From Moffitt Cancer Center, Mayo Clinic

    Bio-IT World | Until recently, Ross Mitchell served as the inaugural AI Officer at the Moffitt Cancer Center in Tampa, Florida. Now he’s offering consulting expertise borne of a long career applying AI to healthcare and health systems.

    Aug 10, 2021
  • Follow the Money: RNA Therapeutics, AI-Driven Therapy Design

    Bio-IT World | Deep Genomics nets cash for AI-designed RNA therapeutics, Strata advances personalized minimal residual disease (MRD) assays, Frontier Medicines goes after the proteome, and more.

    Aug 5, 2021
  • #BioIT21: Insider’s Guide to Making the Most of the Hybrid Program

    Bio-IT World | The Bio-IT World Conference and Expo will be happening both in-person and online this year—giving our community even more options for learning and connection. We’ve been busy marking our schedules and making our plans. Here are our best tips for making the most both the in person and online options.

    Aug 4, 2021
  • NVIDIA’s Synthetic Brain Images, Genomic Research Diversity, New Products

    Bio-IT World | Kings College London uses NVIDIA’s Cambridge-1 supercomputer to build synthetic brain images, Singapore researcher detect SARS-CoV-2 in wastewater, American Heart Association Issues statement on genomic research diversity, and biobank acquisitions. Plus new products from 10x Genomics, Paradigm4, Thermo Fisher, Cresset.

    Aug 3, 2021
  • Russia Will Introduce Special Digital Genetic Passports

    Bio-IT World | Russia plans to introduce special digital genetic passports that will contain genome sequencing of each citizen of the country—the data could be further used for the formation of genetic profiles and identification of susceptibility to diseases, according to recent statements made by some senior officials of the Russian federal government and analysts.

    Jul 29, 2021
  • Duke, Regeneron, Micronoma Named 2021 Bio-IT World Innovative Practices Winners

    Bio-IT World | Bio-IT World has announced the 2021 Innovative Practices Awards winners. Grand prize awards were granted to Duke Cancer Institute with University of California, San Francisco, Micronoma, and Regeneron Pharmaceuticals. Pure Storage and the Folding@home project received honorable mention recognition. All four groups will be presenting their projects at the 2021 Bio-IT World Conference & Expo in Boston in September.

    Jul 28, 2021
  • NHGRI Takes New, WGS Look at Mendelian Diseases

    Bio-IT World | The National Institutes of Health has made a five-year, nearly $80 million commitment to the establishment of a Mendelian Genomics Research Consortium of five clinical laboratories and one data coordinating center. The Consortium will build on previous National Human Genome Research Institute (NHGRI) work to develop new methods for identifying the genetic causes of single-gene diseases.

    Jul 27, 2021